Comparison of Vascular Remodeling Between Different Antianginal Medication Evaluated by Noninvasive ECG-gated Fundus Photographic Evaluation
- Conditions
- Stable Angina
- Interventions
- Registration Number
- NCT01162902
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
Treatments for stable angina includes drug therapy such as calcium-channel blocker, beta blocker, and ACEI/ARB. To obtain good prognosis in patients with coronary artery disease,preventing or correcting the progression of atherosclerosis and dyslipidemia is more important than relieving angina symptom. Dysfunction of microvessel is one of the most important factor in patients with coronary artery disease. Recently, we developed the new non-invasive method of evaluating the microvessel in fundus. With this methods, we will compare the effect of each drug (beta blocker, CCB, ARB).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 150
- Stable angina patients whose coronary lesions is confirmed by angiography or receives PCI
- Unstable Angina/NSTEMI patients who completed PCI for main lesions
- Either systolic > 130mmHg or diastolic > 80mmHg, or patients with anti-hypertensive drugs
- STEMI patients within one month
- Variant Angina
- Liver function abnormality or renal failure
- History of Hypersensitivity to testing drugs
- Severe heart failure(NYHA class>3) or uncorrectable hematologic disease
- Woman possible to be pregnant
- Uncontrolled diabetes
- Expected life span < one year
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Diltiazem treated group Diltiazem treated group Diltiazem 180mg treated group Bisoprolol treated group Bisoprolol treated group Bisoprolol 5mg treated group Candesartan treated group Candesartan treated group Candesartan 32mg treated group
- Primary Outcome Measures
Name Time Method Wall to lumen ratio of fundus vessel baseline, 9 months Measurement of change in the ratio of wall thickness to lumen of the fundus vessel from baseline to 9 month follow up
- Secondary Outcome Measures
Name Time Method Serum markers of inflammation baseline, 9 months CRP
lipid parameter baseline, 9 months Measurement of change in total cholesterol, triglyceride, LDL, small dense LDL, and HDL
Change of nitrate need baseline, 1 months, and 3 months Measure of change of nitrate need
Trial Locations
- Locations (1)
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of