Comparison of Effects Between Amlodipine and Hydrochlorothiazide in Combination With Losartan on 24-hr Central Blood Pressure in Hypertensive Patients
Phase 4
Completed
- Conditions
- Hypertension
- Interventions
- Registration Number
- NCT02294539
- Lead Sponsor
- Chong-Jin Kim
- Brief Summary
The purpose of this study is to investigate which combination therapy is more effective for improving the blood pressure (BP) and AM central SBP in hypertensive patients:Angiotensin II receptor blocker (ARB) plus calcium channel blocker (CCB) or ARB plus diuretics
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 231
Inclusion Criteria
- Hypertension patients not included exclusion criteria
- Mean seated SBP ≥140mmHg in patients with newly Diagnosed
Exclusion Criteria
- msDBP≥110mmHg or ms SBP ≥ 180mmHg at the screening and randomization visit
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Losartan 50mg/amlodipine 5mg Losartan 50mg/Hydrochlorothiazide 12.5mg Once daily, 1T, PO medication Losartan 100mg/amlodipine 5mg Losartan 100mg/Hydrochlorothiazide 25mg Once daily, 1T, PO medication Losartan100 mg/Hydrochlorothiazide25 mg Losartan 100mg/amlodipine 5mg Once daily, 1T, PO medication Losartan50 mg/Hydrochlorothiazide12.5 mg Losartan 50mg/amlodipine 5mg Once daily, 1T, PO medication
- Primary Outcome Measures
Name Time Method change from baseline in msSBP 4 weeks
- Secondary Outcome Measures
Name Time Method change from baseline in AMcSBP 20 weeks
Trial Locations
- Locations (1)
Kyung Hee University Hospital at Gangdong
🇰🇷Seoul, Korea, Republic of