Effect of combination of calcium channel blocking drugs and iron lowering drugs on iron levels in patients with thalassemia major (blood disorder requiring repeated blood transfusions).
Not Applicable
- Conditions
- Health Condition 1: D561- Beta thalassemia
- Registration Number
- CTRI/2019/06/019787
- Lead Sponsor
- Department of Pediatrics
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Patients with serum ferritin >1000 ng/ml
2. Received >10 blood transfusions
3. Patients on stable iron chelation for >6 months
Exclusion Criteria
1. Patients with congenital or acquired heart disease
2. Patients with significant renal disease (serum creatinine >3 times normal or eGFR <30 ml/min/m2)
3. Patients with significant liver disease (ALT/AST >3 times normal)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Percent change in myocardial iron concentrationTimepoint: 0, 6, 12 months
- Secondary Outcome Measures
Name Time Method Percent change in liver iron concentration <br/ ><br>Percent change in serum ferritin value <br/ ><br>Change in LVEF at 12 monthsTimepoint: 0, 6, 12 months