Feasibility, Reproducibility and Acceptance of Muscle Examinations in Patients with Cerebral Palsy

• Conditions: Cerebral palsy; G80

• Registration Number: DRKS00031107
• Lead Sponsor: Deutsches Zentrum für Luft- und Raumfahrt - Institut für Luft- und Raumfahrtmedizin, Muskel- und Knochenstoffwechsel

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-02-06
• Study Completion: 2023-09-20
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

CP group: diagnosed with infantile cerebral palsy with resulting spasticity of the lower extremities.
- Control group: healthy individuals matched for gender, age, and height to participants in the CP group.

All groups:
- Age: 12-18 years
- Ability to consent
- Consent and signed informed consent prior to the study.

Exclusion Criteria

- Limitations of mobility that prevent 90° positions of the ankle joints and knees
- Injuries or illnesses in the past six weeks that interfere with calf muscle contractions or the jump and hop test

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Feasibility of three different active muscle tests (maximal isometric contraction, controlled building-up and breaking-down isometric contraction, constant submaximal isometric contraction), defined as the number of successfully completed muscle tests per subject in both groups. <br>

Secondary Outcome Measures

Name	Time	Method
- Feasibility of isometric muscle contractions of the plantar flexors, defined as duration and constancy of contraction measured by dynamometry.<br>- Repeatability of the muscle architectural parameters fascicle length, pinna angle, muscle thickness, and fascicle curvature of the medial gastrocnemius, using B-mode ultrasound at rest and during dynamic isometric contractions<br>- Repeatability of the indirect stiffness parameter shear wave velocity of the medial gastrocnemius by shear wave elastography at rest and during constant isometric contractions<br>- Repeatability of the generated torque of the plantar flexors by means of dynamometry <br>- Acceptability of the performed tests by means of questionnaire<br><br><br>