The feasibility, reliability and validity of the MOX-accelerometer in measuring daily physical endurance in children with a mitochondrial disorder

Completed

• Conditions: 10027424; mitochondrial encephalomyopathy; mitopathy

• Registration Number: NL-OMON40669
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

Patients:
- aged 4-18 years
- decreased ATP production in fresh muscle (to same extend as descrease in pyruvateoxidation rate) or mutation in gene known to cause mitochondrial disease
- follow-up in NCMD;Heatlhy controls
- Healthy
- Regular education
- Aged 4-18 years

Exclusion Criteria

Patients:
- Fever
- Epilepsia continua
- Altered state of conciousness compared to normal;Healthy controls:
- Regularly seen by a paediatrician
- Complaints of exercise intolerance, muscle complaints or fatigue, more than peers
- Official ADHD diagnosis
- Sibling with neuromuscular or metabolic disease

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The feasibility (% of patients), reliability (test-retest, % of data) and<br /><br>validity (correlation with video of standardized movements, correlation with<br /><br>reported activities) of the MOX-accelerometer in children with a mitochondrial<br /><br>disease</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>na</p><br>