Efficacy and Safety of Preventive Mechanical Ventilation in Adults With Guillain Barré Syndrome
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Guillain Barré Syndrome
- Sponsor
- University of Versailles
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Rate of hospital acquired pneumonia from randomization to study day 90
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of this study is to determine whether early mechanical ventilation can prevent hospital acquired pneumonia in adults with Guillain Barré Syndrome.
Detailed Description
Hospital acquired pneumonia is a common and severe complication of Guillain Barré Syndrome. Several factors have been recognized as predictors of respiratory failure in adults with Guillain Barré Syndrome. They include a time from disease onset and patient admission of less seven days, inability to lift head, impaired swallowing and a forced vital capacity of less than 60% of predictive value. We reasonned that early mechanical ventilation may prevent aspiration which is likely the main cause of pneumonia in these patients.
Investigators
Djillali Annane
Professor in medicine
University of Versailles
Eligibility Criteria
Inclusion Criteria
- •Guillain Barré Syndrome
- •Age of 18 years old or more
- •Inability to lift head
- •Time from onset of motor deficit less than 7 days
- •Written informed consent
Exclusion Criteria
- •Glasgow coma score of less than 8
- •Unstable hemodynamic status
- •Current pneumonia
- •Pregnancy
Outcomes
Primary Outcomes
Rate of hospital acquired pneumonia from randomization to study day 90
Time Frame: Day 90
Secondary Outcomes
- Hospital length of stay(Day 90)
- Tolerance(Day 90)
- Intensive care unit lenght of stay(Day 90)
- Time on a ventilator(Day 90)