PACTR202110646172601Recruiting未知
Vitamin D status in relation to systemic and intestinal inflammation in undernourished children, 6-59 months old
Centre of Excellence for Nutrition0 sites175 target enrollmentStarted: September 28, 2021Last updated:
Trial Snapshot
- Phase
- 未知
- Status
- Recruiting
- Sponsor
- Enrollment
- 175
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 2 Year(s) to 5 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Undernutrition group:
- •MUAC < 12.5 cm and/ or weight-for-height, weight-for-age, height/length-for-age <-2 SD and or bilateral pitting oedema (+ or ++)
- •Good appetite (passed appetite test)
- •Clinically well and alert without medical complications
- •Apparently healthy non-malnourished group:
- •MUAC > 12.5 cm or WHZ > -1 SD but = 2SD, Height-for-age > -1 SD
Exclusion Criteria
- •Fever (ear temperature > 38 ?C)
- •Persistent cough in the past 2 weeks
- •Blood transfusion in the past month
- •Medical record diagnosis of malabsorption syndrome
- •Persistent diarrhoea or vomiting in the past 3 days
- •Chronic medications including anticonvulsants (phenobarbital, carbamazepine, phenytoin), antibiotics (rifampicin, isoniazid), antiretroviral medications (protease inhibitors (PIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs); e.g. efavienz, darunavir and ritonavir
- •Medical record diagnosis of conditions associated with vitamin D hypersensitivity (i.e. sarcoidiosis, primary hyperparathyroidism
- •Children already receiving treatment for vitamin D deficiency
- •Haemoglobin < 70 g/
Investigators
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