The Comparison Of Nerve Blocks In Cesarean Delivery

Not Applicable

Completed

• Conditions: Anesthesia, Obstetrical
• Interventions: Procedure: QLB; Procedure: Intravenous patient controlled analgesia (PCA)

• Registration Number: NCT03333902
• Lead Sponsor: Feng Xia

Brief Summary

The purpose of this study is to investigate the effect of different kinds of popular peripheral nerve blocks for postoperative analgesia after cesarean delivery is completed, compared with traditional epidual analgesia.

Detailed Description

Visual Analogue Scale (VAS) and morphine consumption was adopted to evaluate the pain relief.

Study Timeline

• Study First Submitted: 2017-11-02
• Study First Submitted QC: 2017-11-05
• Study First Posted: 2017-11-07
• Study Start: 2017-12-01
• Primary Completion: 2018-06-30
• Study Completion: 2018-08-30
• Status Verified: 2019-01
• Last Update Submitted: 2019-01-23
• Last Update Posted: 2019-01-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 102

Inclusion Criteria

• American Society of Anesthesiologists (ASA) physical status I or II
• weight from 50 to 70 kilogrammes
• a normal singleton pregnancy
• ≥37 weeks gestation

Exclusion Criteria

• congenital coagulopathy
• anatomic abnormalities
• localized skin infection
• allergy to any of the drugs used

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
QLB type 2	Intravenous patient controlled analgesia (PCA)	Ultrasound-guided, Inject at the point posterior to quadratus lumborum muscle, 0.2% ropivacaine 30mL in each side for a total of 60mL. Subjects also receive an intravenous patient controlled analgesia (PCA) pump of 0.5 mg/mL morphine for 48 hours.
QLB type 2+3	QLB	Ultrasound-guided, conduct both QLB type 2 and 3, 0.2% ropivacaine 15mL in each point of injection, for a total of 60mL. Subjects also receive an intravenous patient controlled analgesia (PCA) pump of 0.5 mg/mL morphine for 48 hours.
epidural anesthesia group (EA)	QLB	Epidural catheter placement was conducted when finishing spinal anesthesia. After surgery, 30 mL saline (placebo) was Injected at the point posterior to the quadratus lumborum in each side for a total of 60mL. We used a single bolus of 0.15% ropivacaine + 2 mg morphine (diluted in 6 ml saline) via epidural cathether. Subjects also receive an intravenous patient controlled analgesia (PCA) pump of 0.5 mg/mL morphine for 48 hours.
QLB type 3	Intravenous patient controlled analgesia (PCA)	Ultrasound-guided, Inject at the point between the quadratus lumborum and the psoas major muscle, 0.2% ropivacaine 30mL in each side for a total of 60mL. Subjects also receive an intravenous patient controlled analgesia (PCA) pump of 0.5 mg/mL morphine for 48 hours.
QLB type 2	QLB	Ultrasound-guided, Inject at the point posterior to quadratus lumborum muscle, 0.2% ropivacaine 30mL in each side for a total of 60mL. Subjects also receive an intravenous patient controlled analgesia (PCA) pump of 0.5 mg/mL morphine for 48 hours.
QLB type 3	QLB	Ultrasound-guided, Inject at the point between the quadratus lumborum and the psoas major muscle, 0.2% ropivacaine 30mL in each side for a total of 60mL. Subjects also receive an intravenous patient controlled analgesia (PCA) pump of 0.5 mg/mL morphine for 48 hours.
QLB type 2+3	Intravenous patient controlled analgesia (PCA)	Ultrasound-guided, conduct both QLB type 2 and 3, 0.2% ropivacaine 15mL in each point of injection, for a total of 60mL. Subjects also receive an intravenous patient controlled analgesia (PCA) pump of 0.5 mg/mL morphine for 48 hours.
epidural anesthesia group (EA)	Intravenous patient controlled analgesia (PCA)	Epidural catheter placement was conducted when finishing spinal anesthesia. After surgery, 30 mL saline (placebo) was Injected at the point posterior to the quadratus lumborum in each side for a total of 60mL. We used a single bolus of 0.15% ropivacaine + 2 mg morphine (diluted in 6 ml saline) via epidural cathether. Subjects also receive an intravenous patient controlled analgesia (PCA) pump of 0.5 mg/mL morphine for 48 hours.

Primary Outcome Measures

Name	Time	Method
the change trend of Visual Analogue Scale (VAS) at rest and movement	0-48 hours postoperatively	The purpose is to view the change of the level of pain assessed by subjects at adjacent time points. We would set 0, 4, 6, 12, 24, 48 hours postoperatively as observational time points.

Secondary Outcome Measures

Name	Time	Method
total morphine consumption	0-48 hours postoperatively	total morphine consumption
complications	0-48 hours postoperatively	nausea, vomiting, retention of urine, lower limb weakness, etc.

Trial Locations

Locations (1)

The First Affiliated Hospital of Sun Yat-Sen University; 🇨🇳 Guangzhou, Guangdong, China