Cognitive behavioural treatment of negative symptoms in patients with schizophrenic disorders
Completed
- Conditions
- SchizophreniaMental and Behavioural Disorders
- Registration Number
- ISRCTN25455020
- Lead Sponsor
- niversity Hospital Tuebingen (Germany)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 198
Inclusion Criteria
1. Schizophrenia (Diagnostic and Statistical Manual of Mental Disorders - fourth edition [DSM-IV] 295.1, 295.2, 295.3, 295.4, 295.6, 295.9)
2. PANSS Modified Negative Syndrome Score =10
3. Fluency of German language
Exclusion Criteria
1. Severe positive symptoms (any item of the standard PANSS positive scale [P1, P2, P3, P4, P5, P6, P7] =6)
2. Severe depression as indicated by PANSS G6 =6
3. Extrapyramidal symptoms
4. Age below 18 or over 55
5. Organic disorder interfering with the central nervous system
6. Verbal IQ <80
7. Diagnosis of substance abuse or substance dependence according to DSM-IV/Structured Clinical Interview for Depression (SCID-I) as primary clinical problem
8. Travel time to the study centre of more than 1 hour
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method PANSS Modified Negative Factor (N1, N2, N3, N4, N6, G7, G16)
- Secondary Outcome Measures
Name Time Method 1. Illness related events<br>2. Scale for the Assessment of Negative Symptoms (SANS)<br>3. Calgary Depression Scale for Schizophrenia (CDSS)<br>4. Clinical Global Impression (CGI)<br>5. Lancashire Quality of Life Profile (LQLP)<br>6. Social Status<br>7. Medication Compliance<br>8. Symptom Checklist 90 Revised (SCL-90-R)<br>9. Frontal Eye Fields (FEF)<br>10. Frankfurt Self-concept Scale (FSKN)<br>11. Neuropsychological assessment