The Role of Central Reward and Satiety Centers in the Etiology of Obesity: Genetic and Environmental Influences
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- The difference in neuronal activity in CNS reward and satiety circuits as represented by BOLD fMRI signal change from baseline (%) in response to food-related stimuli between individuals at high verses low genetic obesity risk.
研究概览
简要总结
The aim of this study is to investigate the effects of genetic and environmental risk factors on central nervous system (CNS) reward and satiety circuits in the etiology of obesity. The investigators will also investigate to what extent the alterations in CNS reward and satiety circuits are a cause or a consequence of the development of obesity.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-75 years
- •Male or female
- •Stable bodyweight (<5% reported weight change during previous 3 months)
- •Women: regular menstruation cycle (to exclude possible menstruation cycle effects)
- •Normal fasting blood glucose
排除标准
- •Left handedness
- •Known diabetes or abnormal fasting blood glucose
- •Serious heart, pulmonary, hepatic or renal disease, malignant or hematological disease
- •Metabolic disorders (uncontrolled adrenal/thyroid disease)
- •Women: irregular menstruation cycle
- •Neurological or psychiatric illness
- •Pregnancy or breast feeding
- •Alcohol abuse
- •Nicotine abuse
- •Claustrophobia or metal implants
- •Visual disability
- •Participation in another study
- •Inability to understand the protocol or to give informed consent
- •Current/chronic use of following medication: antihyperglycemic agents, glucocorticoids, centrally acting drugs, cytostatics, immune suppressants, potentially addictive medications.
结局指标
主要结局
The difference in neuronal activity in CNS reward and satiety circuits as represented by BOLD fMRI signal change from baseline (%) in response to food-related stimuli between individuals at high verses low genetic obesity risk.
时间窗: Baseline (one measurement)
The difference in neuronal activity in CNS reward and satiety circuits as represented by BOLD functional magnetic resonance imaging (fMRI) signal change from baseline (%) in response to food-related stimuli within obesity discordant MZ twin pairs.
时间窗: Baseline (one measurement)
The difference in neuronal activity in CNS reward and satiety circuits as represented by BOLD fMRI signal change from baseline (%) in response to food-related stimuli between lean and obese subjects with either high or low genetic obesity risk.
时间窗: Baseline (one measurement)
次要结局
- The difference within obesity-discordant monozygotic (MZ) twin pairs regarding physical activity level(Baseline (one measurement))
- The difference within obesity-discordant monozygotic (MZ) twin pairs regarding basal metabolic rate(Baseline (one measurement))
- The difference between individuals at high versus those at low genetic obesity risk regarding basal metabolic rate(Baseline (one measurement))
- The difference between individuals at high versus those at low genetic obesity risk regarding autonomic nervous system balance(Baseline (one measurement))
- The difference within obesity-discordant monozygotic (MZ) twin pairs regarding dietary intake(Baseline (one measurement))
- The difference within obesity-discordant monozygotic (MZ) twin pairs regarding autonomic nervous system balance(Baseline (one measurement))
- The difference between individuals at high versus those at low genetic obesity risk regarding fasting circulating biomarker levels(Baseline (one measurement))
- The difference between individuals at high versus those at low genetic obesity risk regarding physical activity level(Baseline (one measurement))
- The difference within obesity-discordant monozygotic (MZ) twin pairs regarding fasting circulating biomarker levels(Baseline (one measurement))
- The difference between individuals at high versus those at low genetic obesity risk regarding dietary intake(Baseline (one measurement))
研究者
RG IJzerman
MD PhD FRCPE, Professor of Internal Medicine, Chair of Diabetology, Director of Diabetes Center VUmc
Amsterdam UMC, location VUmc