Study of the Effect of Inhaled Anesthetics on Diastolic Heart Function Using a Doppler-derived Efficiency Index

Completed

• Conditions: Diastolic Dysfunction; Coronary Artery Disease; General Anesthesia

• Registration Number: NCT00907439
• Lead Sponsor: Washington University School of Medicine

Brief Summary

The purpose of this study is to determine the effect of inhaled anesthetic drugs upon diastolic heart function (heart suction and filling performance) in patients who are undergoing coronary bypass surgery.

Detailed Description

Diastolic heart dysfunction is a significant cause of cardiovascular morbidity and is the cause of symptomatic heart failure in approximately one half of patients who are admitted to hospitals with heart failure symptoms. However, diastolic heart function remains difficult to measure objectively without cardiac catheterization. Diastolic heart dysfunction is also common among patients undergoing coronary bypass grafting (CABG) surgery. Despite the ubiquitous use of inhaled volatile drugs to maintain anesthesia in these patients, their effects upon diastolic heart function remain unclear.

Study Timeline

• Study Start: 2008-11
• Study First Submitted: 2009-05-20
• Study First Submitted QC: 2009-05-20
• Study First Posted: 2009-05-22
• Primary Completion: 2010-10
• Study Completion: 2010-10
• Status Verified: 2010-11
• Last Update Submitted: 2010-11-03
• Last Update Posted: 2010-11-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

• Non-emergent coronary bypass grafting surgery
• Left ventricular ejection fraction of 40% or greater

Exclusion Criteria

• Myocardial infarction within 4 weeks
• Greater than mild cardiac valvular pathology
• Body mass index greater than 35
• Cardiac dysrhythmias or pacemaker therapy
• Left bundle branch block
• Uncontrolled gastroesophageal reflux disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diastolic efficiency index (derived from the parameterized analysis of transmitral early filling Doppler using the paradigm of the ventricle as a damped harmonic oscillator)	Following induction of volatile anesthesia

Secondary Outcome Measures

Name	Time	Method
Diastolic efficiency index (derived from the parameterized analysis of transmitral early filling Doppler using the paradigm of the ventricle as a damped harmonic oscillator)	Following the onset of controlled ventilation

Trial Locations

Locations (1)

Barnes-Jewish Hospital; 🇺🇸 St Louis, Missouri, United States