Arterial Stiffness, Wave Reflections and Renal Failure

Completed

• Conditions: Chronic Renal Failure; Arterial Stiffness; Arterial Wave Reflections

• Registration Number: NCT00354588
• Lead Sponsor: Klinikum Wels-Grieskirchen

Brief Summary

1. Cardiovascular risk is high in patients with renal failure.

2. Cross-sectional studies have indicated a relationship between arterial stiffness and renal function. However, there are no prospective longitudinal studies in the literature.

3. In dialysis patients, arterial stiffness as well as wave reflections, predict mortality. However, there are no data on patients with mild-to-moderate renal impairment available.

4. Therefore, we designed a study to test the hypothesis that: a) measures of arterial stiffness and wave reflections predict the progression of renal impairment in patients with mild-to-moderate renal failure; and b) measures of arterial stiffness and wave reflections predict cardiovascular events in patients with mild-to-moderate renal failure

Detailed Description

Not available

Study Timeline

• Study Start: 2006-01
• Study First Submitted: 2006-07-19
• Study First Submitted QC: 2006-07-19
• Study First Posted: 2006-07-20
• Primary Completion: 2010-10
• Study Completion: 2010-10
• Status Verified: 2010-11
• Last Update Submitted: 2010-11-03
• Last Update Posted: 2010-11-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 115

Inclusion Criteria

• chronic renal failure patients (KDOQI III, IV) undergoing regular control visits at our nephrology department
• > 19 years
• written informed consent

Exclusion Criteria

• atrial fibrillation
• valvular heart disease
• severely impaired systolic function
• no informed consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
renal endpoint		doubling serum creatinine, need for dialysis, renal transplantation

Trial Locations

Locations (1)

Cardiology and Nephrology Department Klinikum Wels; 🇦🇹 Wels, Austria