The genetics of autism spectrum disorder

Not Applicable

• Conditions: Autism spectrum disorder; Mental and Behavioural Disorders; Childhood autism

• Registration Number: ISRCTN79375633
• Lead Sponsor: Chinese University of Hong Kong

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-10-31
• Last Update Posted: 18 March 2024
• Study Completion: 2025-09-30

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Current inclusion criteria as of 03/11/2023:

1. Reported by the parents to be autistic or autism spectrum disorder (ASD) with confirmation from health care professional workers. The probands must have received a valid and reliable assessment and must meet cutoffs for autism spectrum or autism. (e.g. the newest Autism Diagnostic Observation Schedule [ADOS] algorithms to be used for Modules 1 - 3 and the original cutoff algorithms to be used for Module 4; or a clinical Best Estimate Diagnosis,” of Autistic Disorder, Asperger’s Disorder, or Pervasive Developmental Disorder-Not Otherwise Specified [PDD-NOS], according to the Diagnostic and Statistical Manual of Mental Disorders [DSM-IV-TR]).
2. Age: The proband must be aged 2 or above when the phenotype measures are administered, any first and second-degree relatives and their parents (autistic or not) will also be recruited in anticipation that these samples will be valuable resources for further understanding of the
genetic factors that might contribute to the phenotype.
3. Being ethnic Chinese

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Previous inclusion criteria:

1. Reported by the parents to be autistic or autism spectrum disorder (ASD) with confirmation from health care professional workers. The probands must have received a valid and reliable assessment and must meet cutoffs for autism spectrum or autism. (e.g. the newest Autism Diagnostic Observation Schedule [ADOS] algorithms to be used for Modules 1 - 3 and the original cutoff algorithms to be used for Module 4; or a clinical Best Estimate Diagnosis,” of Autistic Disorder, Asperger’s Disorder, or Pervasive Developmental Disorder-Not Otherwise Specified [PDD-NOS], according to the Diagnostic and Statistical Manual of Mental Disorders [DSM-IV-TR]).
2. Age: The proband must be between 2 to 18 years of age when the phenotype measures are administered, any first and second-degree relatives and their parents (autistic or not) will also be recruited in anticipation that these samples will be valuable resources for further understanding of the genetic factors that might contribute to the phenotype.
3. Being ethnic Chinese

Exclusion Criteria

Current exclusion criteria as of 03/11/2023:

1. With significant injury, abnormality, or disease having effects upon the brain, extensive complications during birth or pregnancy (careful screening will be carried out for those who stayed in the hospital for more than 3 days after birth)
2. With sensory or motor deficits that preclude the effective use of the diagnostic tools
3. Other known genetic disorder: e.g. Down's syndrome, or Fragile X syndrome
4. Those diagnosed with a known genetic disorder, and those with a psychiatric disorder requiring medication

_____

Previous exclusion criteria:

1. With significant injury, abnormality, or disease having effects upon the brain, extensive complications during birth or pregnancy (careful screening will be carried out for those who stayed in the hospital for more than 3 days after birth)
2. With sensory or motor deficits that preclude the effective use of the diagnostic tools
3. With significant nutritional and psychological deprivation
4. Other known genetic disorder: e.g. Down's syndrome, or Fragile X syndrome
5. Those diagnosed with a known genetic disorder, and those with a psychiatric disorder requiring medication

Study & Design

• Study Type: Observational
• Study Design: Not specified