To find endophenotypes of patients with autism spectrum disorder by phenotype and genotype correlation

Chinese University of Hong Kong0 sites100 target enrollmentOctober 31, 2022

Overview

Phase: N/A
Intervention: Not specified
Conditions: Not specified
Sponsor: Chinese University of Hong Kong
Enrollment: 100
Status: Active, Not Recruiting
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

No summary available.

Registry

who.int

Start Date

October 31, 2022

End Date

September 30, 2025

Last Updated

2 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Chinese University of Hong Kong

Eligibility Criteria

Inclusion Criteria

•Current inclusion criteria as of 03/11/2023:
•1\. Reported by the parents to be autistic or autism spectrum disorder (ASD) with confirmation from health care professional workers. The probands must have received a valid and reliable assessment and must meet cutoffs for autism spectrum or autism. (e.g. the newest Autism Diagnostic Observation Schedule \[ADOS] algorithms to be used for Modules 1 \- 3 and the original cutoff algorithms to be used for Module 4; or a clinical Best Estimate Diagnosis,” of Autistic Disorder, Asperger’s Disorder, or Pervasive Developmental Disorder\-Not Otherwise Specified \[PDD\-NOS], according to the Diagnostic and Statistical Manual of Mental Disorders \[DSM\-IV\-TR]).
•2\. Age: The proband must be aged 2 or above when the phenotype measures are administered, any first and second\-degree relatives and their parents (autistic or not) will also be recruited in anticipation that these samples will be valuable resources for further understanding of the
•genetic factors that might contribute to the phenotype.
•3\. Being ethnic Chinese
•Previous inclusion criteria:
•1\. Reported by the parents to be autistic or autism spectrum disorder (ASD) with confirmation from health care professional workers. The probands must have received a valid and reliable assessment and must meet cutoffs for autism spectrum or autism. (e.g. the newest Autism Diagnostic Observation Schedule \[ADOS] algorithms to be used for Modules 1 \- 3 and the original cutoff algorithms to be used for Module 4; or a clinical Best Estimate Diagnosis,” of Autistic Disorder, Asperger’s Disorder, or Pervasive Developmental Disorder\-Not Otherwise Specified \[PDD\-NOS], according to the Diagnostic and Statistical Manual of Mental Disorders \[DSM\-IV\-TR]).
•2\. Age: The proband must be between 2 to 18 years of age when the phenotype measures are administered, any first and second\-degree relatives and their parents (autistic or not) will also be recruited in anticipation that these samples will be valuable resources for further understanding of the genetic factors that might contribute to the phenotype.
•3\. Being ethnic Chinese

Exclusion Criteria

•Current exclusion criteria as of 03/11/2023:
•1\. With significant injury, abnormality, or disease having effects upon the brain, extensive complications during birth or pregnancy (careful screening will be carried out for those who stayed in the hospital for more than 3 days after birth)
•2\. With sensory or motor deficits that preclude the effective use of the diagnostic tools
•3\. Other known genetic disorder: e.g. Down's syndrome, or Fragile X syndrome
•4\. Those diagnosed with a known genetic disorder, and those with a psychiatric disorder requiring medication
•Previous exclusion criteria:
•1\. With significant injury, abnormality, or disease having effects upon the brain, extensive complications during birth or pregnancy (careful screening will be carried out for those who stayed in the hospital for more than 3 days after birth)
•2\. With sensory or motor deficits that preclude the effective use of the diagnostic tools
•3\. With significant nutritional and psychological deprivation
•4\. Other known genetic disorder: e.g. Down's syndrome, or Fragile X syndrome