ISRCTN79375633进行中（未招募）未知
To find endophenotypes of patients with autism spectrum disorder by phenotype and genotype correlation
适应症
试验速览
- 阶段
- 未知
- 状态
- 进行中（未招募）
- 入组人数
- 100
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 性别
- All
入选标准
- •Current inclusion criteria as of 03/11/2023:
- •1. Reported by the parents to be autistic or autism spectrum disorder (ASD) with confirmation from health care professional workers. The probands must have received a valid and reliable assessment and must meet cutoffs for autism spectrum or autism. (e.g. the newest Autism Diagnostic Observation Schedule [ADOS] algorithms to be used for Modules 1 - 3 and the original cutoff algorithms to be used for Module 4; or a clinical Best Estimate Diagnosis,” of Autistic Disorder, Asperger’s Disorder, or Pervasive Developmental Disorder-Not Otherwise Specified [PDD-NOS], according to the Diagnostic and Statistical Manual of Mental Disorders [DSM-IV-TR]).
- •2. Age: The proband must be aged 2 or above when the phenotype measures are administered, any first and second-degree relatives and their parents (autistic or not) will also be recruited in anticipation that these samples will be valuable resources for further understanding of the
- •genetic factors that might contribute to the phenotype.
- •3. Being ethnic Chinese
- •Previous inclusion criteria:
- •1. Reported by the parents to be autistic or autism spectrum disorder (ASD) with confirmation from health care professional workers. The probands must have received a valid and reliable assessment and must meet cutoffs for autism spectrum or autism. (e.g. the newest Autism Diagnostic Observation Schedule [ADOS] algorithms to be used for Modules 1 - 3 and the original cutoff algorithms to be used for Module 4; or a clinical Best Estimate Diagnosis,” of Autistic Disorder, Asperger’s Disorder, or Pervasive Developmental Disorder-Not Otherwise Specified [PDD-NOS], according to the Diagnostic and Statistical Manual of Mental Disorders [DSM-IV-TR]).
- •2. Age: The proband must be between 2 to 18 years of age when the phenotype measures are administered, any first and second-degree relatives and their parents (autistic or not) will also be recruited in anticipation that these samples will be valuable resources for further understanding of the genetic factors that might contribute to the phenotype.
- •3. Being ethnic Chinese
排除标准
- •Current exclusion criteria as of 03/11/2023:
- •1. With significant injury, abnormality, or disease having effects upon the brain, extensive complications during birth or pregnancy (careful screening will be carried out for those who stayed in the hospital for more than 3 days after birth)
- •2. With sensory or motor deficits that preclude the effective use of the diagnostic tools
- •3. Other known genetic disorder: e.g. Down's syndrome, or Fragile X syndrome
- •4. Those diagnosed with a known genetic disorder, and those with a psychiatric disorder requiring medication
- •Previous exclusion criteria:
- •1. With significant injury, abnormality, or disease having effects upon the brain, extensive complications during birth or pregnancy (careful screening will be carried out for those who stayed in the hospital for more than 3 days after birth)
- •2. With sensory or motor deficits that preclude the effective use of the diagnostic tools
- •3. With significant nutritional and psychological deprivation
- •4. Other known genetic disorder: e.g. Down's syndrome, or Fragile X syndrome
- •5. Those diagnosed with a known genetic disorder, and those with a psychiatric disorder requiring medication
研究者
相似试验
招募中
不适用
Identification of autism-spectrum disorder traitsICD-10 F-DiagnosesF00-F99Mental and behavioural disordersDRKS00026020Klinik der Psychiatrie, Psychotherapie und Psychosomatik der Uniklinik RWTH Aachen.150
已完成
不适用
Investigating Neuroimaging Endophenotypes for Autism Spectrum DisorderAutism Spectrum DisorderNCT02720588National Taiwan University Hospital90
已完成
不适用
Clinical and Neurophysiological Evolutions Through a Functional Rehabilitation of Social Communication in ASDAutistic DisorderNCT02444117University Hospital, Tours200
终止
1 期
Deep repetitive transcranial magnetic stimulation for autism spectrum disorderAutism spectrum disorderACTRN12612001208897Dr. Peter Enticott80
招募中
不适用
Phenotypic Exploration of Autism Spectrum Disorders Retrospective and Prospective DataAutism Spectrum DisorderNCT04923854Assistance Publique - Hôpitaux de Paris1,500