Taste and smell changes in testicular cancer patients treated with cisplatin based chemotherapy

Completed

Conditions: smaak- en geurfunctie
taste and smell
10038597

Registration Number: NL-OMON37350

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 140

Inclusion Criteria

Cancer patients:
- Testicular cancer patients treated with cisplatin based chemotherapy
- Age range 18-50
- Ability to comprehend Dutch (both reading and writing)
- Signed informed consent;Healthy controls:
- Healthy males
- Age 18-50 years
- Ability to comprehend Dutch (both reading and writing)
- Signed informed consent

Exclusion Criteria

Cancer patients
- Mental disability
-Smoking (cross-sectional part);Healthy controls:
- Mental disability
- Ever diagnosed with cancer
- History of taste and smell abnormalities
- Smoking (cross-sectional part)

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Scores of gustatory and olfactory function of patients with disseminated<br /><br>testicular cancer treated with cisplatin based chemotherapy will be<br /><br>investigated using physiological tests (taste strips and Sniffin Sticks*) and<br /><br>using a questionnaire on taste and smell function to investigate the subjective<br /><br>perception of taste and smell function among these patients. During the<br /><br>chemotherapeutic treatment the measurements will be re-assessed several times<br /><br>to investigate possible changes in gustatory and olfactory function before,<br /><br>during and after chemotherapy. Measurements will also be carried out 1, 3, 5<br /><br>and 7 years after chemotherapy to investigate possible changes in gustatory and<br /><br>olfactory function in the long-term. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary parameters are food preference, dietary intake, quality of life,<br /><br>BMI, body composition (bone and fat mass), audiograms, BRS, blood glucose level<br /><br>and DNA. We will focus on changes in these parameters due to changes in<br /><br>gustatory and olfactory function as a consequence of chemotherapy. </p><br>