Clinical Relevance of the Reverse Lipopolysaccharide Transport Pathway in Patients With Acute Peritonitis An Observational Prospective Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 27
- 试验地点
- 1
- 主要终点
- Perioperative plasma concentration in 3HM
研究概览
简要总结
When there is infection in the intra-abdominal area, bacteria secrete toxins that are absorbed by the peritoneum. These toxins then bind to lipoproteins (which carry cholesterol in the blood) and are eliminated by the liver. Phospholipid transfer protein (PLTP) is a protein that facilitates the binding of bacterial toxins to lipoproteins and thus their elimination.
The objective of this study is to study the relationship between PLTP and the elimination of bacterial toxins in humans. A better understanding of the elimination of these toxins will lead to a better understanding of the disease. The ultimate objective is to improve the management of intra-abdominal infections.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •person who has given oral consent (patient or family member)
- •pre-operative SEPSIS criteria (qSOFA >=2) or vasopressor or mechanical ventilation treatment
- •admitted to the operating room for suspected generalized secondary peritonitis
排除标准
- •person not affiliated to national health insurance
- •person under legal protection (curatorship, guardianship)
- •person under court order
- •pregnant, parturient or breastfeeding woman
- •immunosuppression (HIV infection, corticosteroid treatment > 0.15 mg/kg/day prednisolone equivalent > 2 weeks, immunosuppressive treatment, primary cellular immune deficiency)
- •decision to limit or stop therapy
结局指标
主要结局
Perioperative plasma concentration in 3HM
时间窗: 24 hours postoperatively
次要结局
未报告次要终点