Link Between Plasma Citrulline and Lipopolysaccharide Concentrations in the Critically Ill

• Conditions: Critically Ill

• Registration Number: NCT02902276
• Lead Sponsor: Centre Hospitalier Universitaire de Besancon

Brief Summary

In critically ill patients, the small bowel permeability is increased, leading to bacterial translocation, and systemic inflammatory response syndrome.

Plasma citrulline is a validated biomarker of functional enterocyte mass. Lipopolysaccharide (LPS) is a part of Gram negative bacteria, and plasma LPS concentration is a biomarker of bacterial translocation. The link between plasma citrulline and LPS in the critically ill is unknown. Investigators hypothesize that patients presenting with low plasma citrulline concentration, with presumed altered small bowel function, would have an increased phenomenon of bacterial translocation, and increased plasma LPS concentration. Investigators aimed to evaluate the link between plasma citrulline and LPS concentrations in critically ill patients at the time of ICU admission.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-07
• Study First Submitted: 2016-08-11
• Status Verified: 2016-09
• Study First Submitted QC: 2016-09-14
• Last Update Submitted: 2016-09-14
• Study First Posted: 2016-09-15
• Last Update Posted: 2016-09-15
• Primary Completion: 2017-02
• Study Completion: 2017-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Critically ill patients requiring ICU admission for at least 48 hours
• Adults

Exclusion Criteria

• Chronic small bowel disease
• Chronic renal failure (clearance of creatinine < 50 mL/min)
• Pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Plasma citrulline concentration	Up to 12 hours after admission in the unit	biological assay
plasma lipopolysaccharide concentration	Up to 12 hours after admission in the unit	biological assay

Trial Locations

Locations (1)

Centre Hospitalier Universitaire de Besançon; 🇫🇷 Besançon, France