Study of two anti-thyroid drug treatment regimens in young people with thyrotoxicosis

Not Applicable

Completed

• Conditions: Thyrotoxicosis in children, endocrinology; Nutritional, Metabolic, Endocrine; Thyrotoxicosis

• Registration Number: ISRCTN82088322
• Lead Sponsor: The Newcastle upon Tyne NHS Foundation Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-10-12
• Study Completion: 2015-11-01
• Last Update Posted: 27 May 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 128

Inclusion Criteria

1. All patients with thyrotoxicosis aged between 2 and 16 years at the time of diagnosis
2. Thyrotoxicosis will be diagnosed by the paediatrician on the basis of the clinical picture and the biochemistry [suppressed thyroid stimulating hormone (TSH) with high thyroid hormone levels]
3. Child must consent/assent or consent via parent/guardian must be gained prior to any study-specific procedures

Exclusion Criteria

1. Known toxic adenoma/toxic hyperplasia [germline activating thyroid-stimulating hormone receptor (TSHR) mutation]
2. McCune Albright Syndrome
3. Previous episodes of thyrotoxicosis
4. Known allergic response to any of the study medication or ingredients as per Summary of Product Characteristics (SmPC)
5. Previous participation in this study

Study & Design

• Study Type: Interventional
• Study Design: Not specified