A randomised controlled trial of thyroxine in preterm infants under 28 weeks gestatio

Completed

• Conditions: Premature infants; Neonatal Diseases; Disorders related to short gestation and low birth weight, not elsewhere classified

• Registration Number: ISRCTN89493983
• Lead Sponsor: iverpool Women's NHS Foundation Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2008-03-10
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

All infants with gestational age under 28 weeks at birth

Exclusion Criteria

1. Infants born to mother with known thyroid disease or on antithyroid medications during pregnancy
2. Infants born to mother who are on amiodarone during pregnancy
3. Infants diagnosed with major congenital or chromosomal abnormalities known to affect thyroid function or brain development
4. Maternal death during or within 5 days after childbirth

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome will be the width of the sub-arachnoid space measured using cranial ultrasound and head circumference at 36 weeks Corrected Gestational Age (CGA).

Secondary Outcome Measures

Name	Time	Method
1. Width of the sub-arachnoid space measured using cranial ultrasound at 36 weeks Corrected Gestational Age (CGA)<br>2. Head circumference at 36 weeks CGA