Identify Clinical Conditions That Increase Circulating DNA Levels
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 130
- 试验地点
- 1
- 主要终点
- Different diseases will be analysed for the levels of DNA circulating in the blood
研究概览
简要总结
The investigators are developing a test that is expected to measure the amount of radiation a patient has been exposed to after a nuclear bomb. The investigator will do this by measuring the DNA in the patients blood from cells killed by the radiation.
Many diseases and medical conditions can put DNA in the blood. The investigator needs to know how much DNA in order to better interpret our radiation detection test. Therefore, the investigator is collecting blood from several patients with different diseases or medical conditions and also healthy volunteers to measure their DNA content.
Patients that will be included in this study are pregnant women, patients who have suffered a pulmonary embolism within the past 48 hours, patients who have suffered from myocardial infarction in the past 48 hours, patients with autoimmune diseases and health patients.
详细描述
The investigator will collect 8 mL (one and one half teaspoons) of blood one time only. The investigator may also collect the patient's past medical history, test results and disease treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients must be adults in one of the following categories:
- •Suffered a pulmonary embolism within the past 48 hours
- •Myocardial infarction in the past 48 hours
- •Diagnosed with an autoimmune disease
- •Adults age 18-80
- •Self-declared healthy adults
- •Patients must be willing to undergo a blood draw
- •Patients must provide study-specific informed consent prior to study entry
排除标准
- •Patients not meeting the above inclusion criteria
结局指标
主要结局
Different diseases will be analysed for the levels of DNA circulating in the blood
时间窗: blood will be tested up to 1 year after collection
To determine what medical conditions and disease states might increase circulating DNA levels at a magnitude similar to whole body irradiation.
次要结局
未报告次要终点