Comparison of Intravenous Versus Nebulized Dexmedetomidine for Attenuation of Laryngoscopy and Intubation-Induced Sympathoadrenal Stress Response-A Randomised, comparative clinical study
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Nebulized dexmedetomidine may provide a favourable alternative to intravenous route for attenuation of sympathoadrenal stress response to intubation
研究概览
简要总结
General anaesthesia with muscle relaxant using control ventilation involve laryngoscopy and tracheal intubation
increase in sympathetic activity noted during laryngoscopy and endotracheal incubation
There is a necessity to Blunt this response to prevent deleterious effect like LVF MI increase ICP arrhythmia.
highly selective dexmedetomidine can be used in prevent this effect
Dexmedetomidine block release of catecholamines and inhibit sympathetic activity and decrease hemodynamic response to laryngoscopy and intubationNebulized dexmedetomidine may provide a favourable alternative to intravenous route for attenuation of sympathoadrenal stress response to intubation without any significant sideeffects with added advantage of preventing postoperative sore throat
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
入选标准
- •A) Patients posted for elective surgery under general anesthesia requiring endotracheal intubation B) Age: 18- 60 years C)Gender: Either gender D)ASA I, II and III.
排除标准
- •Patient refusal Dexmedetomidine allergy Preoperative sore throat or upper respiratory infection Significant cardiac pulmonary or hepatorenal disease Body mass index more then thirty kg per meter swerve Predictive difficult airway Pregnant patient.
结局指标
主要结局
Nebulized dexmedetomidine may provide a favourable alternative to intravenous route for attenuation of sympathoadrenal stress response to intubation
时间窗: Till 10 minutes after intubation
次要结局
- Preventing post operative sore throat(Post operative 24 hour)