Research study aiming at investigating the potential effectiveness and safety of a treatment for chronic advanced heart failure of ischemic origin. The treatment is based on patient own stem cells that will be collected and guided to the cardiac cells lineage before being injected into the heart muscle.

Recruitment & Eligibility

Status: ot Recruiting

Sex: All

Target Recruitment: 240

Inclusion Criteria

Eligible patients must meet all of the following inclusion criteria:
1.Age = 18 and < 80 years.
2.Systolic dysfunction with LVEF = 35% as assessed by echocardiography.
3.Ischemic heart failure without known need for revascularization.
4.Total MLHFQ score > 30.
5.Ability to perform a Six-Minute Walk Test > 100 m and = 400 m.
6.History of hospitalization for HF within 12 months prior to screening or treatment in an out-patient clinic with intravenous vasoactive therapy (including vasodilators, positive inotropic agents and vasopressors) or diuretics for worsening HF within 12 months prior to screening.
7.Be or must have been within the previous 12 months in NYHA class III or IV or INTERMACS class 4, 5, 6 or 7, and at the time of inclusion, must be at least in NYHA class II or greater.
8.Use of ACE inhibitor and/or ARB; and beta blocker, for at least 3 months prior to screening visit, unless intolerant or contraindicated.
9.Stable dosing of ACE inhibitor, ARB, beta blocker, aldosterone blocker, and diuretics for at least one month prior to screening visit, defined as =50% change in total dose of each agent.
10. Willing and able to give written informed consent.

Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 120
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 120

Exclusion Criteria

Eligible patients must meet none of the following exclusion criteria:
1.Women who are pregnant, confirmed by a positive urine or serum hCG laboratory test at screening.
2.Women of child-bearing potential without a negative serum or urine pregnancy test at screening or who are not practicing a reliable form of birth control. Women who are postmenopausal (12 months of spontaneous amenorrhea or 6 months of spontaneous amenorrhea with serum FSH level > 40 IU/m or 6 weeks post surgical bilateral oophorectomy) or surgically sterile are not considered to be of child-bearing potential. Reliable contraception includes surgical sterilization, hormonal contraception, or double-barrier methods.
3.Men refusing to exercise a reliable form of contraception.
4.Myocardial infarction, unstable angina or percutaneous coronary intervention (PCI) within 90 days prior to screening, or CABG surgery within 180 days prior to screening.
5.Patient on a cardiac transplant list or previously received any solid organ transplant.
6.Previously underwent cardiac surgery with remodeling procedure, left ventricular assist device placement or cardiomyoplasty. This exclusion does not apply to patients who underwent ventricularplasty without placements device >1 year ago.
7.Patient has undergone cardiac resynchronization therapy (CRT) within 6 months (180 days) prior to screening.
8.Severe uncontrolled HF requiring need for intensive intravenous diuretics or inotropic support within 1 month prior to screening.
9.Inability to perform a Six-Minute Walk Test due to physical limitations other than HF including:
a.Severe peripheral vascular disease
b.Severe pulmonary disease or chronic obstructive pulmonary disease (COPD) limiting exercise
c.Orthopedic limitations, severe muscular diseases, any other joint or muscular disease or neurological disorder (such as an old stroke or neuropathy) limiting the ability to walk for 6 minutes.
10.Dependence on chronic oral steroid therapy.
11.Stroke or transient ischemic attack leading to limitations in lower extremities or occurring within 180 days prior to screening.
12.Active myocarditis, constrictive pericarditis, restrictive, hypertrophic or congenital cardiomyopathy.
13.BMI < 19 or > 45.
14.Left ventricular thrombus.
15.Left ventricular wall thickness < 8mm visualized in more than 50% of LV, and defined as a LV no-go zone
16.LV aneurysm or candidate for surgical aneurysmectomy.
17.Sustained VT or VF which led to AICD therapy (shock) within 3 months prior to screening.
18.Primary significant organic valvular heart disease.
19.Moderate to severe aortic valve disease precluding catheter entry into the LV.
20.Mechanical prosthetic valve in aortic or mitral position.
21.Chronic infection or active malignancy.
22.Patient has compromised renal function as reflected by a serum creatinine level >3.0 mg/dL (>0.265 mmol/l) or is currently on dialysis.
23.Hematocrit < 28%.
24.Atherosclerosis and/or tortuosity of the aorta, iliac or femoral arteries of a degree that could impede or preclude the safe retrograde passage of the delivery catheter.
25.Chronic immunosuppressive therapy due to inflammatory or systemic disease.
26.Patient tested positive for HIV 1 or 2, Hepatitis B or C, HTLV 1 or 2 (if requested by regulations) or syphilis.
27.Exposure to any previous experimental cell or angiogenic therapy and/or myocardial laser therapy and/or therapy with another investigational drug within 60 days prior to scre