Randomized comparative clinical study to evaluate the efficacy of guduchyadi ghrita and go-ghrita along with panchvalkala kwatha yoni prakshalana in paripluta yonivyapad W.S.R to pelvic inflammatory disease

This clinical study aims to evaluate and compare the efficacy of Guduchyadi Ghrita and Go-Ghrita, both administered orally along with Panchvalkala Kwatha yoni prakshalana, in the management of Paripluta Yonivyapad, a condition correlated with Pelvic Inflammatory Disease (PID). The primary objective is to assess changes in key symptoms such as pelvic pain, dyspareunia, abnormal vaginal discharge, fever, and dysuria between the two treatment groups. Secondary objectives include a detailed study of the disease’s Ayurvedic and modern pathogenesis and the identification of any adverse drug reactions.

The study is a randomized, open-label, comparative clinical trial conducted over 30 days on 60 married women aged 21 to 50 years, diagnosed with PID. Participants are divided equally into two groups. Group A receives Guduchyadi Ghrita orally (5 ml with milk twice daily) along with Panchvalkala Kwatha for yoni prakshalana (10 gm per vagina for 7 days post-menstruation), while Group B receives Go-Ghrita with the same external procedure. Patients are recruited from the OPD and IPD of Madan Mohan Malviya Government Ayurved College, Udaipur, and written consent is obtained prior to participation.

Inclusion criteria include sexually active women with symptoms like lower abdominal pain, abnormal discharge, backache, dyspareunia, and menstrual irregularities, while exclusion criteria rule out pregnant women and those with severe systemic or gynecological conditions requiring surgery or with malignancies. Randomization is done using a computer-generated sequence and allocation is concealed using SNOSE method.

Assessment is based on subjective symptom scoring and objective findings including laboratory investigations such as CBC, ESR, RBS, LFT, RFT, urine analysis, Pap smear, and pelvic USG, both before and after treatment. Follow-up is conducted every 15 days to monitor progress and compliance. The trial aims to determine the safety and efficacy of these Ayurvedic interventions in managing PID through both traditional and modern diagnostic parameters.