Investigation of the Effects of Selective Exercise Training in Multiple Sclerosis
- Conditions
- ExerciseMultiple Sclerosis
- Interventions
- Other: exercise
- Registration Number
- NCT04853654
- Lead Sponsor
- Sanko University
- Brief Summary
Selective exercise programs specific to muscle groups, with the workload to be done in line with the muscle's own structure, can enable more strength to be released with less fatigue in MS, and this increase in strength can increase balance and functional activities. to determine the effects of type training (selective exercise training), eccentric and concentric training on function, balance, fatigue and muscle architecture.
- Detailed Description
Recovery and enhancement of muscle function in MS is one of the main goals in physiotherapy and rehabilitation. In literature studies, it is stated that eccentric and concentric exercises are effective exercise approaches in increasing strength and reducing fatigue. However, the best exercise method is not yet clear in terms of providing better performance adaptation with less fatigue. Considering the architectural features of the lower extremity muscles, it is aimed to increase the angle of pennation with programs that include concentric strengthening of the quadriceps, gastro-soleus and gastrocnemius muscles, which are suitable muscle groups to produce large forces by design. With programs that include eccentric strengthening of the hamstring and tibialis anterior muscles that function in a wide range of motion and have high excursion ability, it is aimed to increase fiber length.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 33
- Between the ages of 18-50,
- With an Extended Disability Status Scale (EDSS) score of 4 or less,
- No regular exercise habit
- Able to walk on the treadmill,
- No pregnancy,
- Not receiving corticosteroid treatment in the last month,
- Fampridine etc. in the last 1 month. not taking medication,
- Patients who have not received Botox treatment in the last 6 months
patients who do not agree to volunteer
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Downhill walking exercise downhill walking training on the treadmill for 2 days/week Uphill walking exercise uphill walking training on the treadmill for 2 days/week Selective training exercise selective training on lower extremity for 3 days/week
- Primary Outcome Measures
Name Time Method muscle architecture parameter 1 Change from Baseline at 8th weeks and 12th weeks The pennation angle were evaluated with Ultrasound
muscle architecture parameter 2 Change from Baseline at 8th weeks and 12th weeks The fiber length were evaluated with Ultrasound
muscle architecture parameter 3 Change from Baseline at 8th weeks and 12th weeks The muscle thickness were evaluated with Ultrasound
Muscle strength Change from Baseline at 8th weeks and 12th weeks low extremity muscles were evaluated with hand dynamometer
- Secondary Outcome Measures
Name Time Method walking fatigue Change from Baseline at 8th weeks and 12th weeks Walking Fatigue Index
perceived fatigue Change from Baseline at 8th weeks and 12th weeks Fatigue Severity Scale
physical fatigue Change from Baseline at 8th weeks and 12th weeks Modified Borg Scale before and after 6-minute walking test
static balance Change from Baseline at 8th weeks and 12th weeks Single standing tests
Functional activities 1 Change from Baseline at 8th weeks and 12th weeks timed-up go test
Functional activities 2 Change from Baseline at 8th weeks and 12th weeks 2-minute walk test
Functional activities 3 Change from Baseline at 8th weeks and 12th weeks 25-feet walk test
dynamic balance Change from Baseline at 8th weeks and 12th weeks 4 square step tests
Trial Locations
- Locations (1)
Zekiye İpek Katırcı Kırmacı
🇹🇷Gaziantep, Turkey