Investigation of the Effects of Selective Exercise Training on Muscle Architecture, Balance, Function and Fatigue in Multiple Sclerosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- Muscle strength
研究概览
简要总结
Selective exercise programs specific to muscle groups, with the workload to be done in line with the muscle's own structure, can enable more strength to be released with less fatigue in MS, and this increase in strength can increase balance and functional activities. to determine the effects of type training (selective exercise training), eccentric and concentric training on function, balance, fatigue and muscle architecture.
详细描述
Recovery and enhancement of muscle function in MS is one of the main goals in physiotherapy and rehabilitation. In literature studies, it is stated that eccentric and concentric exercises are effective exercise approaches in increasing strength and reducing fatigue. However, the best exercise method is not yet clear in terms of providing better performance adaptation with less fatigue. Considering the architectural features of the lower extremity muscles, it is aimed to increase the angle of pennation with programs that include concentric strengthening of the quadriceps, gastro-soleus and gastrocnemius muscles, which are suitable muscle groups to produce large forces by design. With programs that include eccentric strengthening of the hamstring and tibialis anterior muscles that function in a wide range of motion and have high excursion ability, it is aimed to increase fiber length.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Between the ages of 18-50,
- •With an Extended Disability Status Scale (EDSS) score of 4 or less,
- •No regular exercise habit
- •Able to walk on the treadmill,
- •No pregnancy,
- •Not receiving corticosteroid treatment in the last month,
- •Fampridine etc. in the last 1 month. not taking medication,
- •Patients who have not received Botox treatment in the last 6 months
排除标准
- •patients who do not agree to volunteer
研究组 & 干预措施
Selective training
selective training on lower extremity for 3 days/week
干预措施: exercise (Other)
Downhill walking
downhill walking training on the treadmill for 2 days/week
干预措施: exercise (Other)
Uphill walking
uphill walking training on the treadmill for 2 days/week
干预措施: exercise (Other)
结局指标
主要结局
Muscle strength
时间窗: Change from Baseline at 8th weeks and 12th weeks
low extremity muscles were evaluated with hand dynamometer
muscle architecture parameter 1
时间窗: Change from Baseline at 8th weeks and 12th weeks
The pennation angle were evaluated with Ultrasound
muscle architecture parameter 2
时间窗: Change from Baseline at 8th weeks and 12th weeks
The fiber length were evaluated with Ultrasound
muscle architecture parameter 3
时间窗: Change from Baseline at 8th weeks and 12th weeks
The muscle thickness were evaluated with Ultrasound
次要结局
- walking fatigue(Change from Baseline at 8th weeks and 12th weeks)
- Functional activities 2(Change from Baseline at 8th weeks and 12th weeks)
- Functional activities 3(Change from Baseline at 8th weeks and 12th weeks)
- perceived fatigue(Change from Baseline at 8th weeks and 12th weeks)
- physical fatigue(Change from Baseline at 8th weeks and 12th weeks)
- static balance(Change from Baseline at 8th weeks and 12th weeks)
- Functional activities 1(Change from Baseline at 8th weeks and 12th weeks)
- dynamic balance(Change from Baseline at 8th weeks and 12th weeks)
研究者
zekiye ipek katırcı kırmacı
assistant professor
Sanko University