Effect of Exercise on Muscle Mass, Functional Capacity and Physical Activity in Community-dwelling Elderly With Sarcopenia in Jamaica
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 38
- 试验地点
- 1
- 主要终点
- Functional endurance
研究概览
简要总结
This study examined the effects of combined-modality exercise training (resistance, endurance, flexibility and balance) on muscle mass, muscle function and physical activity in community-dwelling elderly living in Jamaica who had been characterised as having sarcopenia.
详细描述
Community-dwelling seniors aged 60 years and older were screened for muscle mass and function (grip strength and walk speed) and persons with sarcopenia were identified using the European Working Group on Sarcopenia in Older Persons (EWGSOP) algorithm for case finding (N=1344). Of the 77 seniors with sarcopenia, 38 consented to participate and were randomly allocated to receive 6 months combined-modality high intensity treadmill based exercise and a 'usual care' home exercise programme. A comparison of the effects of treatment assignment on muscle mass, function, fitness, physical activity level and disability was done. Participants in the supervised combined-modality high intensity group were required to attend sessions 3 times per week; participants in the home exercise programme were required to attend 1 supervised session at the start of their 6-month intervention. Outcomes were assessed at baseline and at the end of the 6-month intervention. Data were analysed using standard statistical parametric and non-parametric methods including repeated measures analysis of variance to determine changes in outcomes and regression to establish determinants of outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •over 60 years old,
- •independently ambulant, with or without an assistive device
- •mentally competent to give informed consent and follow exercise instructions
排除标准
- •a history of stroke with residual disability
- •a diagnosis of cancer
- •neuromuscular disorders
- •auto-immune disorders
- •severe arthritis rendering participation in an exercise programme difficult
- •unstable cardiovascular disease which renders exercise unsafe
研究组 & 干预措施
Sarcopenia and combined-modality high intensity supervised exercise training
Participants were given Treadmill exercise training, lower extremity progressive resistance training using a Cybex leg press machine, and a 1-hour adaptive physical activity (APA) programme in which participants were required to walk for 12 minutes through an obstacle course in which they must clear 10 cm high boards, climb 3 steps and walk sideways through hula-hoops placed on the floor all the while dual-tasking i.e. waving at strategically placed signs, conversing while walking and picking up objects. Participants also performed exercises at the parallel bars which included weight-shifting from leg to leg and half-squatting; they were also guided through seated upper- and lower-limb stretching exercises for range of motion and trunk mobility. All exercise sessions were supervised by physiotherapists. For two of the weekdays on which participants did not attend supervised training, they were asked to walk for 30 minutes at home and perform the APA exercises described above.
干预措施: High intensity exercise (Other)
Sarcopenia and 'usual care' unsupervised exercise
Participants were required to do 5-12 chair rises and also 30-minutes walking 5 days per week. Upper limb and trunk flexibility exercises were also taught.
干预措施: Usual care home exercise (Other)
结局指标
主要结局
Functional endurance
时间窗: 6 months
Distance walked in 6 minutes
Lower extremity (LE) functional strength
时间窗: 6 months
1-repetition maximum (RM) strength
Appendicular lean mass index
时间窗: 6 months
dual energy x-ray absorptiometry (DEXA) measured appendicular lean mass summed and divided by height squared, expressed in kg/m2
Disability
时间窗: 6 months
Lawton Instrumental Activities of Daily Living scale: minimum score = 0 (low function, dependent); maximum score = 8 (high function, independent). Lower scores indicate a worse outcome.
Fat-free mass
时间窗: 6 months
dual energy x-ray absorptiometry (DEXA) determined: fat mass subtracted from weight, expressed in kg
self-selected walk speed
时间窗: 6 months
speed in the timed-10-metre walk
Accelerometry
时间窗: 6 months
weekly energy expenditure
Balance
时间窗: 6 months
Berg balance test score: minimum score = 0, maximum score = 56. Lower values indicate worse outcome
次要结局
- Timed-up-and-go(6 months)
- Depression(6 months)