The Impact of Chronic E-Cigarette Usage on Microvascular Health
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 41
- 试验地点
- 2
- 主要终点
- Endothelial dependent dilation
研究概览
简要总结
The study is focused on investigating the mechanisms involved in microvascular health in subjects that use e-cigarettes frequently. To explore microvascular health, different techniques and compounds. For one of the tests, iontophoresis, the drug's use will be stored and handled as described by the approved IND and non-IDS plan.
详细描述
Electronic cigarettes or e-cigarettes have become increasingly popular, due to their promotion as a healthy alternative to traditional tobacco cigarettes. However, there are large discrepancies of knowledge in understanding how these e-cigarettes affect the subjects health and the way their body uses oxygen. The overall goal of this study is to evaluate e-cigarettes usage on subjects health.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 29 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •e-Cig users arm
- •Inclusion Criteria:
- •Between 18 and 29 years of age
- •Used e-cigarettes with nicotine (≥3 times/week for ≥6 months)
排除标准
- •17 years old and younger or 30 years old or older.
- •Former combustible tobacco user/ former smoker
- •Use of cigarettes for 15 days or more in the past 60 days
- •Use of other tobacco products (cigars, hookah, smokeless), marijuana and/or illicit or prescription drugs weekly or more frequently in the past 60 days
- •Evidence of cardiovascular, pulmonary, renal, hepatic, metabolic, cerebral diseases or sleep disorders
- •Disorder or use of medication that affects cardiopulmonary health
- •Evidence of pregnancy or current nursing
- •Non e-Cig using arm
- •- Between 18 and 29 years of age
- •17 years old and younger or 30 years old and older
- •Use of cigarettes or other tobacco products more than 50 times in their lifetime.
- •Evidence of cardiovascular, pulmonary, renal, hepatic, metabolic, cerebral diseases or sleep disorders
- •Disorder or use of medication that affects cardiopulmonary health
- •Evidence of pregnancy or current nursing
研究组 & 干预措施
Never Users
Use of cigarettes or other tobacco products less than 50 times in their lifetime.
干预措施: E-cig use (Other)
Chronic e-cigs users
Used e-cigarettes with nicotine (≥3 times/week for ≥6 months)
干预措施: E-cig use (Other)
结局指标
主要结局
Endothelial dependent dilation
时间窗: Participation is one week
Endothelial-dependent dilation will be assessed using laser doppler speckle contrast in both groups through the intervention
Neurogenic response
时间窗: Participation is one week
Neurogenic response will be assessed using axon reflex in both groups through the intervention
次要结局
未报告次要终点