The Impact of Chronic E-Cigarette Usage on Microvascular Health

Recruiting

• Conditions: E-Cig Use

• Registration Number: NCT06860698
• Lead Sponsor: Virginia Commonwealth University

Brief Summary

The study is focused on investigating the mechanisms involved in microvascular health in subjects that use e-cigarettes frequently. To explore microvascular health, different techniques and compounds. For one of the tests, iontophoresis, the drug's use will be stored and handled as described by the approved IND and non-IDS plan.

Detailed Description

Electronic cigarettes or e-cigarettes have become increasingly popular, due to their promotion as a healthy alternative to traditional tobacco cigarettes. However, there are large discrepancies of knowledge in understanding how these e-cigarettes affect the subjects health and the way their body uses oxygen. The overall goal of this study is to evaluate e-cigarettes usage on subjects health.

Study Timeline

• Study Start: 2023-07-14
• Study First Submitted: 2025-02-24
• Study First Submitted QC: 2025-02-28
• Status Verified: 2025-03
• Study First Posted: 2025-03-06
• Last Update Submitted: 2025-03-06
• Last Update Posted: 2025-03-11
• Primary Completion: 2025-09-30
• Study Completion: 2025-09-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

• Between 18 and 29 years of age
• Used e-cigarettes with nicotine (≥3 times/week for ≥6 months)

Exclusion Criteria

• 17 years old and younger or 30 years old or older.
• Former combustible tobacco user/ former smoker
• Use of cigarettes for 15 days or more in the past 60 days
• Use of other tobacco products (cigars, hookah, smokeless), marijuana and/or illicit or prescription drugs weekly or more frequently in the past 60 days
• Evidence of cardiovascular, pulmonary, renal, hepatic, metabolic, cerebral diseases or sleep disorders
• Disorder or use of medication that affects cardiopulmonary health
• Evidence of pregnancy or current nursing

Non e-Cig using arm

Inclusion

• Between 18 and 29 years of age

Exclusion

• 17 years old and younger or 30 years old and older
• Use of cigarettes or other tobacco products more than 50 times in their lifetime.
• Evidence of cardiovascular, pulmonary, renal, hepatic, metabolic, cerebral diseases or sleep disorders
• Disorder or use of medication that affects cardiopulmonary health
• Evidence of pregnancy or current nursing

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Endothelial dependent dilation	Participation is one week	Endothelial-dependent dilation will be assessed using laser doppler speckle contrast in both groups through the intervention
Neurogenic response	Participation is one week	Neurogenic response will be assessed using axon reflex in both groups through the intervention

Trial Locations

Locations (1)

Virginia Commonwealth University; 🇺🇸 Richmond, Virginia, United States