High Flow Nasal Cannula vs Noninvasive Ventilation in Patients With Hypoxic Respiratory Failure Following Blunt Chest Trauma

Not Applicable

Completed

• Conditions: Blunt Injury of Thorax

• Registration Number: NCT05527431
• Lead Sponsor: Ain Shams University

Brief Summary

to compare high flow nasal cannula against noninvasive ventilation in patients with non-sever blunt chest trauma in improvement of oxygenation, need for intubation and mechanical ventilation within 28 days

Detailed Description

Not available

Study Timeline

• Study Start: 2022-08-01
• Study First Submitted: 2022-08-18
• Study First Submitted QC: 2022-08-31
• Study First Posted: 2022-09-02
• Status Verified: 2023-08
• Primary Completion: 2024-01-01
• Study Completion: 2024-04-01
• Last Update Submitted: 2024-06-03
• Last Update Posted: 2024-06-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Age ≥18 y,
• Willing and able to provide written informed consent prior to performing study procedures,
• currently hospitalized and requiring medical care for non-sever blunt chest trauma (abbreviated injury severity scale ≤ 2) SpO2 90% or less while breathing 10 L/min.

Exclusion Criteria

• Contraindications of noninvasive ventilation (face trauma or surgery, airway obstruction, upper gastrointestinal tract bleeding, disturbed level of consciousness), -smoker
• intubation for any cause other than respiratory cause

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
PaO2/FiO2 ratio	3 successive days	mean value of three successive PaO2/FiO2 ratio in mmHg between both groups

Secondary Outcome Measures

Name	Time	Method
Discomfort score	3 successive days	Discomfort related to oxygen delivery devices will be evaluated using a 10- point numeric scale which low number is low discomfort.

Trial Locations

Locations (1)

Ain Shams University hospitals; 🇪🇬 Cairo, Egypt