Effects of topical steroids in patients with eosinophilic esophagitis (EoE).
Recruiting
- Conditions
- Eosinophilic esophagitis, etiology, pathophysiology, epithelial barrier function, permeability, steroids, treatment, therapy.Eosinofiele oesofagitis, etiologie, pathofysiologie, epitheliale barrierefunctie, permeabiliteit, steroiden, behandeling, therapie.
- Registration Number
- NL-OMON25172
- Lead Sponsor
- Academic Medical Center, Amsterdam, The Netherlands
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 12
Inclusion Criteria
1. Previous diagnosis of EoE confirmed by histopathology e.g. presence of >15 eosinophilic granulocytes per high power field (hpf) in mid-esophageal biopsies before the start of any therapy;
2. Written informed consent;
Exclusion Criteria
1. Inability to stop PPI, H2-receptor antagonist or prokinetic drug for 8 weeks;
2. Use of systemic corticosteroids, leukotriene inhibitors, or monoclonal antibodies, in the two month period preceding the study;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Tissue impedance, intercellular spaces, and mucosal permeability to small molecules before and after treatment with 500 µg fluticasone propionate twice daily for 8 weeks.
- Secondary Outcome Measures
Name Time Method umbers of esophageal intraepithelial eosinophils and mast cells before and after treatment with 500 µg fluticasone propionate twice daily for 8 weeks.