Effects of topical corticosteroids on esophageal epithelial permeability changes and inflammation in patients with eosinophilic esophagitis

Completed

• Conditions: allergic esophagitis; Idiopathic eosinophilic esophagitis; 10017969; 10001708

• Registration Number: NL-OMON37559
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 11

Inclusion Criteria

* Previous diagnosis of EoE confirmed by histopathology e.g. presence of >15 eosinophilic granulocytes per high power field (hpf) in mid-esophageal biopsies before the start of any therapy
* Written informed consent
* Age 18 * 75 years

Exclusion Criteria

* Inability to stop topical corticosteroids
* Inability to stop PPI, H2-receptor antagonist or prokinetic drug for 8 weeks
* Use of systemic corticosteroids, leukotriene inhibitors, or monoclonal antibodies, in the two month period preceding the study
* Use of anticoagulants
* Use of NSAIDs
* History of peptic ulcer disease
* History of Barrett*s esophagus
* History of GI cancer
* History of GI tract surgery (except appendectomy)
* ASA class IV or V

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Tissue impedance, intercellular spaces, and mucosal permeability to small<br /><br>molecules before and after treatment.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Numbers of esophageal intraepithelial eosinophils and mast cells before and<br /><br>after treatment.<br /><br>- Tissue impedance, intercellular spaces and permeability to small molecules<br /><br>and the number of esophageal intraepithelial mast cells and eosinophils before<br /><br>and after 8 weeks of topical corticosteroid therapy are correlated.</p><br>