Effect of vitamin C administration on bladder discomfort caused by Foley catheter insertion after surgery in patients undergoing transurethral bladder tumor resectio
- Conditions
- Neoplasms
- Registration Number
- KCT0007684
- Lead Sponsor
- Asan Medical Center
- Brief Summary
The group that received vitamin C exhibited a significantly lower incidence of moderate or greater CRBD immediately postoperatively compared with the control group (17 [28.8%] vs. 40 [67.8%], p < 0.001, relative risk [95% confidence interval] = 0.426 [0.274–0.656]). The vitamin C group also showed a significantly lower incidence of moderate or greater CRBD at 1 and 2 h postoperatively compared with the control group (10 [16.9%] vs. 25 [42.4%], p = 0.003; and 5 [8.5%] vs. 16 [27.1%], p = 0.008, respectively). However, there was no significant difference in the incidence of moderate or greater CRBD 6 h postoperatively. Patient satisfaction scores were significantly higher in the vitamin C group than in the control group (5.0 ± 1.3 vs. 4.4 ± 1.4, p = 0.009).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 118
Patients who are
1) scheduled transurethral resection of bladder tumor under general anesthesia
2) aged 20 to 79 years
3) American Society of Anesthesiologists (ASA) Physical Status I or III
4) voluntary participation in this clinical study
1) Change in surgical plans (e.g. conversion to open surgery)
2) Medical history or condition of overactive bladder, neurogenic bladder, or bladder outflow obstruction
3) Gout
4) Renal or ureter stone
5) Hemochromatosis
6) Daily intake of vitamin C
7) Patient refusal
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of CRBD above a moderate grade
- Secondary Outcome Measures
Name Time Method Incidence of CRBD above a moderate grade;Numeric rating scale;Patient satisfaction;Postoperative opioid requirement;Vitamin C-related adverse effects