Effects of intra-operative vitamin C administration on postoperative catheter-related bladder discomfort: A randomized, double-blind, placebo-controlled study
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 118
研究概览
简要总结
The group that received vitamin C exhibited a significantly lower incidence of moderate or greater CRBD immediately postoperatively compared with the control group (17 [28.8%] vs. 40 [67.8%], p < 0.001, relative risk [95% confidence interval] = 0.426 [0.274–0.656]). The vitamin C group also showed a significantly lower incidence of moderate or greater CRBD at 1 and 2 h postoperatively compared with the control group (10 [16.9%] vs. 25 [42.4%], p = 0.003; and 5 [8.5%] vs. 16 [27.1%], p = 0.008, respectively). However, there was no significant difference in the incidence of moderate or greater CRBD 6 h postoperatively. Patient satisfaction scores were significantly higher in the vitamin C group than in the control group (5.0 ± 1.3 vs. 4.4 ± 1.4, p = 0.009).
研究设计
- 研究类型
- Interventional Study
入排标准
- 年龄范围
- 20(Year) 至 79(Year)（—）
- 性别
- All
入选标准
- •Patients who are
- •1) scheduled transurethral resection of bladder tumor under general anesthesia
- •2) aged 20 to 79 years
- •3) American Society of Anesthesiologists (ASA) Physical Status I or III
- •4) voluntary participation in this clinical study
排除标准
- •1) Change in surgical plans (e.g. conversion to open surgery)
- •2) Medical history or condition of overactive bladder, neurogenic bladder, or bladder outflow obstruction
- •4) Renal or ureter stone
- •5) Hemochromatosis
- •6) Daily intake of vitamin C
- •7) Patient refusal