The effect of Astaxanthin on the expression of genes involved in WNT/ß-catenin pathway in granulosa cells and inflammatory factors in the serum of PCOs patients candidate for ART

Phase 3

Recruiting

• Conditions: Poly cystic ovarian syndrome.; Polycystic ovarian syndrome; E28.2

• Registration Number: IRCT20221005056092N1
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 40

Inclusion Criteria

Diagnosis of Poly cystic ovary syndrome based on Rotterdam criteria
People are in the age range of 18 to 40 years

Exclusion Criteria

Pregnancy
Adrenal hyperplasia and androgen secreting tumors
Male infertility factors

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measurment of serum cytokine levels in patients with polycystic ovary syndrome. Timepoint: At the beginning of the study before the start of the intervention and two months after the start of astaxanthin. Method of measurement: ELIZA.;Measuring the expression level of Wnt/ß-catenin signaling pathway genes in patients' granulosa cells. Timepoint: Two months after the start of astaxanthin. Method of measurement: Real time PCR test.;Measuring the level of expression of the phosphorylated and dephosphorylated form of beta-catenin protein. Timepoint: Two months after the start of astaxanthin. Method of measurement: Western blot test.

Secondary Outcome Measures

Name	Time	Method
Checking the quality of oocytes. Timepoint: Two months after taking astaxanthin. Method of measurement: Observation with inverted microscope.;Checking the rate of fertilization fertilization. Timepoint: Two months after taking astaxanthin. Method of measurement: Observation with microscope.