Preoxygenation With High Flow Nasal Cannula Prolongs Normoxia Time During Induction of Anaesthesia of Bariatric Patients and is Superior to Conventional Preoxygenation With Face Mask.

Not Applicable

• Conditions: Compare Preoxygenation Methods in Bariatric Patients
• Interventions: Other: Preoxygenation with High Flow Nasal Cannula; Other: Preoxygenation via face mask

• Registration Number: NCT04965610
• Lead Sponsor: Staedtisches Klinikum Karlsruhe

Brief Summary

To compare preoxygenation for induction of general anaesthesia with High Flow Nasal Cannula vs preoxygenation with face mask in patients undergoing bariatric surgery. The hypothesis is that preoxygenation with High Flow Nasal Cannula prolongs normoxia time during induction of anaeshesia and is superior to conventional preoxygenation with face mask. Primary endpoint will be the time during which spO2 \> 92 %. Secondary endpoint will be paCO2.

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-07
• Study First Submitted: 2021-07-07
• Study First Submitted QC: 2021-07-07
• Last Update Submitted: 2021-07-07
• Study First Posted: 2021-07-16
• Last Update Posted: 2021-07-16
• Study Start: 2021-10
• Primary Completion: 2022-10
• Study Completion: 2022-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• age over 18
• elective bariatric surgery
• written consent

Exclusion Criteria

• preexisting lung diseases, congenital heart diseases
• known difficult airway
• SpO2 < 92% under ambient air conditions
• known diaphragmal hernia
• clinically relevant reflux

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Preoxygenation via THRIVE/High Flow Nasal Cannula	Preoxygenation with High Flow Nasal Cannula	Patients receive preoxygenation for induction of general anaesthesia via High Flow Nasal Cannula for the duration of 5 minutes. After that the induction agents will be given. Now arterial blood gases will be drawn every 2 minutes and the SpO2 will be measured until the 6th apnoeic ABG or if the SpO2 decreases to 92%. After that normal intubation follows.
Preoxygenation via face mask (PROX)	Preoxygenation via face mask	Patients receive preoxygenation for induction of general anaesthesia via tight fitting face mask for the duration of 5 minutes. After that the induction agents will be given. Now arterial blood gases will be drawn every 2 minutes and the SpO2 will be measured until the 6th apnoeic ABG or if the SpO2 decreases to 92%. After that normal intubation follows.

Primary Outcome Measures

Name	Time	Method
Normoxia time SpO2 > 92%	10 Minutes after induction	Time in which the SpO2 remains \> 92% while patient is apnoeic

Secondary Outcome Measures

Name	Time	Method
paCO2	10 Minutes after induction	Increase in arterial CO2 during Apnoea