Comparison of Effects of Oxycodone and Sufentanil on Cardiovascular Stress Induced by Tracheal Intubation in the Patients With Coronary Heart Disease Undergoing Major Noncardiac Surgery

Not Applicable

Completed

• Conditions: Cardiovascular
• Interventions: Drug: Oxycodone 10mg; Drug: Sufentanil

• Registration Number: NCT04121416
• Lead Sponsor: Shengjing Hospital

Brief Summary

To evaluate the effect of oxycodone and sufentanil in preventing cardiovascular responses to tracheal intubation in the patients with coronary heart disease (CHD).

Detailed Description

Laryngoscopy and tracheal intubation can provoke an increase of blood pressure (BP) and/or HR \[1.2\]. This hemodynamic stress may lead to an imbalance between myocardial oxygen consumption and supply and therefore induce myocardial ischemia, which may be endurable in the patients with normal cardiovascular condition but is potential harmful to the patients with coronary heart disease. Thus it is critical to attenuate the cardiovascular stress induced by laryngoscopy and endotracheal intubation in the high risk patients.

Study Timeline

• Status Verified: 2019-04
• Study Start: 2019-04-01
• Primary Completion: 2019-08-31
• Study Completion: 2019-09-19
• Study First Submitted: 2019-10-02
• Study First Submitted QC: 2019-10-08
• Last Update Submitted: 2019-10-08
• Study First Posted: 2019-10-09
• Last Update Posted: 2019-10-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 50

Inclusion Criteria

The coronary angiography from each patient showed that lesions exist in at least one main coronary artery

Exclusion Criteria

a history of reactive airway disease, gastroesophageal reflux, morbid obesity, a known or predicted difficult airway

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Oxycodone group	Oxycodone 10mg	-
Sufentanil group	Sufentanil	-

Primary Outcome Measures

Name	Time	Method
blood pressure(SBP)、diastolic blood pressure(DBP)、mean arterial pressure(MAP)	one second before anesthesia induction, the moment when tracheal catheter passes through glottis and at 1, 3, 5 min after tracheal intubation	Under local anesthesia invasive artery line was put to the patients to monitor systolic blood pressure(SBP)、diastolic blood pressure(DBP)、mean arterial pressure(MAP)

Trial Locations

Locations (1)

shengjing hospital of China medical university; 🇨🇳 Shenyang, Liao Ning, China