A Study on the Gastrointestinal Disease and Helicobacter Pylori Controlled Long Non-coding RNA
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Expression of THRIL, PACER
研究概览
简要总结
Helicobacter pylori (H.pylori) is a major human pathogenic bacterium in gastric mucosa which is linked to the development of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. However the regulatory mechanism of H.pylori-induced immune response is not clear. Long non-coding RNA (lncRNA) has recently emerged as key post-transcriptional regulators of gene expression, differentiation. The investigators had a preliminary results which THRIL (TNFα and hnRNPL related immunoregulatory lincRNA) and PACER(p50-associated COX-2 extragenic RNA) played a potential role in H.pylori induced inflammatory cascade. However, there wasn't a previous study about expression of THRIL, PACER in a human tissue. Therefore, the investigators aimed to evaluate the expression of THRIL, PACER in patients with gastrointestinal disease according to H.pylori infection.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Over 19 years old
- •Patients with gastric ulcer
- •Patients with duodenal ulcer
- •Patients with stomach cancer
- •Patients with gastrointestinal discomfort symptoms
排除标准
- •Patients who has done helicobacter pylori eradication
- •Patients who has undergone gastrectomy
- •Patients who has undergone endoscopic submucosal dissection
- •Patients with active upper gastrointestinal bleeding
结局指标
主要结局
Expression of THRIL, PACER
时间窗: Within 2 weeks after EGD
Expression of THRIL, PACER according to Helicobacter pylori infection by Real-time aRT-PCR
次要结局
未报告次要终点