A Study on the Gastrointestinal Disease and Helicobacter Pylori Controlled Long Non-coding RNA
Overview
- Phase
- Not Applicable
- Sponsor
- Yonsei University
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Expression of THRIL, PACER
Overview
Brief Summary
Helicobacter pylori (H.pylori) is a major human pathogenic bacterium in gastric mucosa which is linked to the development of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. However the regulatory mechanism of H.pylori-induced immune response is not clear. Long non-coding RNA (lncRNA) has recently emerged as key post-transcriptional regulators of gene expression, differentiation. The investigators had a preliminary results which THRIL (TNFα and hnRNPL related immunoregulatory lincRNA) and PACER(p50-associated COX-2 extragenic RNA) played a potential role in H.pylori induced inflammatory cascade. However, there wasn't a previous study about expression of THRIL, PACER in a human tissue. Therefore, the investigators aimed to evaluate the expression of THRIL, PACER in patients with gastrointestinal disease according to H.pylori infection.
Study Design
- Study Type
- Observational
- Observational Model
- Case Only
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 19 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Over 19 years old
- •Patients with gastric ulcer
- •Patients with duodenal ulcer
- •Patients with stomach cancer
- •Patients with gastrointestinal discomfort symptoms
Exclusion Criteria
- •Patients who has done helicobacter pylori eradication
- •Patients who has undergone gastrectomy
- •Patients who has undergone endoscopic submucosal dissection
- •Patients with active upper gastrointestinal bleeding
Outcomes
Primary Outcomes
Expression of THRIL, PACER
Time Frame: Within 2 weeks after EGD
Expression of THRIL, PACER according to Helicobacter pylori infection by Real-time aRT-PCR
Secondary Outcomes
No secondary outcomes reported