NCT02056093Unknown不适用
Breathing Pattern Variability, Respiratory Discomfort and Work of Breathing in Proportional Assist Ventilation And Neurally Adjusted Ventilator Assist
Pierre and Marie Curie University2 个研究点 分布在 1 个国家目标入组 16 人开始时间: 2013年9月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 16
- 试验地点
- 2
- 主要终点
- Breathing pattern variability
研究概览
简要总结
In spontaneously breathing mechanically ventilated patients, the adequacy between the patient's demand and the level of respiratory support delivered by the ventilator is a major clinical issue. Neurally adjusted ventilator assist (NAVA) and proportional assist ventilation (PAV) have been developed to adapt the level of assistance to the patient's demand. These two modes have been compared to pressure support ventilation (PSV) but have not been compared to each other.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Intubated patients.
- •Mechanical ventilation for a respiratory reason.
- •Expected duration of Mechanical ventilation > 48 hrs.
- •Spontaneous breathing.
- •Sedations stopped for more than 24 hours.
排除标准
- •- Main contra indications to NAVA: gastro-oesophageal surgery in the previous 12 months, oesophageal obstruction, gastro-esophageal bleeding in the previous 30 days, history of esophageal varices, facial trauma or surgery, neuromuscular diseases, individuals with known or suspected phrenic nerve dysfunction.
- •Main contra indications to PAV: airway leak, body weight <25 kg, neuromuscular diseases.
- •Hemodynamic instability defined as the current administration of vasopressors or inotropic drugs.
- •Severe hypoxemia defined as PaO2/FiO2 ratio <
- •Decision to withhold life-sustaining treatment.
- •Pregnant women.
- •Minors < 18 years.
结局指标
主要结局
Breathing pattern variability
时间窗: February 2014
The coefficient of variation (standard deviation divided by the mean) of the tidal volume (expressed in %)
次要结局
- Patient-ventilator asynchrony(February, 2014)
研究者
Matthieu SCHMIDT
Dr
Pierre and Marie Curie University
研究点 (2)
Loading locations...
相似试验
终止
不适用
Variable Ventilation During Acute Respiratory FailureAcute Respiratory FailureNCT01083277Boston Medical Center7
撤回
不适用
Response to NonInvasive Mechanical Ventilation According to the Breathing PatternNeuromuscular DisordersChest Wall DisordersObesity Hypoventilation Syndrome (OHS)NCT01991535Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
已完成
不适用
Asynchrony index and breathing patterns of acute exacerbation COPD patients assisted with noninvasive pressure support ventilation and neurally adjusted ventilatory assistTCTR20171016005A7
已完成
不适用
Comparison of Breathing Pattern During Neurally Adjusted Ventilatory Assist Ventilation and Pressure Support VentilationRespiratory System AbnormalitiesNCT01614873Centre d'Investigation Clinique et Technologique 80510
Unknown
不适用
Inflammation and Distribution of Pulmonary Ventilation Before and After Tracheal Intubation in ARDS PatientsAcute Hypoxemic Respiratory FailureAcute Respiratory Distress SyndromeNCT03513809Pontificia Universidad Catolica de Chile40