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Clinical Trials/NCT02056093
NCT02056093
Unknown
N/A

Breathing Pattern Variability, Respiratory Discomfort and Work of Breathing in Proportional Assist Ventilation And Neurally Adjusted Ventilator Assist

Pierre and Marie Curie University1 site in 1 country16 target enrollmentSeptember 2013
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ConditionsAcute Respiratory Failure

Overview

Phase
N/A
Intervention
Not specified
Conditions
Acute Respiratory Failure
Sponsor
Pierre and Marie Curie University
Enrollment
16
Locations
1
Primary Endpoint
Breathing pattern variability
Last Updated
12 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

In spontaneously breathing mechanically ventilated patients, the adequacy between the patient's demand and the level of respiratory support delivered by the ventilator is a major clinical issue. Neurally adjusted ventilator assist (NAVA) and proportional assist ventilation (PAV) have been developed to adapt the level of assistance to the patient's demand. These two modes have been compared to pressure support ventilation (PSV) but have not been compared to each other.

Registry
clinicaltrials.gov
Start Date
September 2013
End Date
February 2014
Last Updated
12 years ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Sponsor
Pierre and Marie Curie University
Responsible Party
Principal Investigator
Principal Investigator

Matthieu SCHMIDT

Dr

Pierre and Marie Curie University

Eligibility Criteria

Inclusion Criteria

  • •Intubated patients.
  • •Mechanical ventilation for a respiratory reason.
  • •Expected duration of Mechanical ventilation \> 48 hrs.
  • •Spontaneous breathing.
  • •Sedations stopped for more than 24 hours.

Exclusion Criteria

  • •- Main contra indications to NAVA: gastro-oesophageal surgery in the previous 12 months, oesophageal obstruction, gastro-esophageal bleeding in the previous 30 days, history of esophageal varices, facial trauma or surgery, neuromuscular diseases, individuals with known or suspected phrenic nerve dysfunction.
  • •Main contra indications to PAV: airway leak, body weight \<25 kg, neuromuscular diseases.
  • •Hemodynamic instability defined as the current administration of vasopressors or inotropic drugs.
  • •Severe hypoxemia defined as PaO2/FiO2 ratio \<
  • •Decision to withhold life-sustaining treatment.
  • •Pregnant women.
  • •Minors \< 18 years.

Outcomes

Primary Outcomes

Breathing pattern variability

Time Frame: February 2014

The coefficient of variation (standard deviation divided by the mean) of the tidal volume (expressed in %)

Secondary Outcomes

  • Patient-ventilator asynchrony(February, 2014)

Study Sites (1)

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