Trans-thoracic Ultrasound VS Invasive Pressure of the Left Atrium

• Conditions: Myocardial Dysfunction

• Registration Number: NCT03012308
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

As part of cardiac and hemodynamic evaluation of patients, echocardiographic measurements allow indirect evaluation of left ventricular filling pressures (LVFP). These ultrasound parameters, including mitral valve doppler and mitral ring doppler (in particular the E / E 'ratio), are well validated in medical cardiology and in some resuscitation patients. The measurement of filling pressures is an important daily element in the medical management of patients in intensive care, in particular on the hemodynamic and respiratory levels. No studies have evaluated the relevance of these markers in a postoperative context of cardiac surgery. Indeed, the surgery alters the cardiac function, which could modify the values of the echocardiographic parameters and their predictability. Left atrium pressure (LAP) directly reflects LVFP and is measured in cardiac surgical resuscitation by a surgically placed catheter as part of routine institutional care and will serve as gold-standard. To study the clinical significance of these LAP and LVFP values estimated by cardiac ultrasound, we will study their correlation with clinical and ultrasound signs of acute lung edema (ALE).

Detailed Description

Not available

Study Timeline

• Study Start: 2016-12-20
• Status Verified: 2017-01
• Study First Submitted: 2017-01-04
• Study First Submitted QC: 2017-01-04
• Study First Posted: 2017-01-06
• Last Update Submitted: 2017-05-11
• Last Update Posted: 2017-05-12
• Primary Completion: 2017-12-20
• Study Completion: 2017-12-20

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patient hospitalized in surgical resuscitation for cardiac surgery with heart-lung bypass machine

Exclusion Criteria

• No consent
• Mitral valve surgery
• severe MI / severe mitral narrowing.
• Absence of POG catheter
• Urgent surgery
• Heart transplant / mechanical assistance
• Classics: minors, pregnant women, guardianship / curatorship / safeguarding,

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Compare the mean values of LAP between the group "high filling pressures" and the group "non-high filling pressures"	6 postoperative hours of cardiac surgery of patients hospitalized in surgical resuscitation

Trial Locations

Locations (1)

Service Réanimation chirurgicale cardio-vasculaire - NHC; 🇫🇷 Strasbourg, France