Conversations With AI Chatbots Increase Short-Term Vaccine Intentions But Do Not Outperform Standard Public Health Messaging
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 930
- 试验地点
- 1
- 主要终点
- Change in intent to vaccinate child against HPV within the next 12 months
研究概览
简要总结
The goal of this clinical trial is to test whether short conversations with large language model (LLM) chatbots can persuade vaccine-hesitant parents to vaccinate their children against human papillomavirus (HPV). The study compares two chatbot styles to official public health information and to a no-message control. Parents of HPV-eligible children first complete a survey about their attitudes toward the HPV vaccine and their main concerns. They are then randomly assigned to read public health materials, have a three-minute conversation with either a default-style chatbot or a conversational-style chatbot tailored to their concern, or receive no message. The main outcome is change in intent to vaccinate immediately after the intervention, with follow-up surveys at 15 and 45 days.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults aged 18 years and up
- •Living in Canada, the UK, or the USA
- •At least one child eligible for HPV vaccine based on country-specific guidelines who has not received any doses of the vaccine or whose vaccination status is unknown
排除标准
- •Failure to pass attention checks
- •Identified as non-human respondents by reCAPTCHA or other automated bot detection
研究组 & 干预措施
No Message
No Intervention
Default-style LLM chatbot
A large language model chatbot (GPT-4o) that delivers tailored persuasive messages to parents about HPV vaccination, using the model's default style with longer, structured responses. Participants engage in a three-minute, multi-turn conversation, with responses personalized to their top-rated vaccine concern identified in a pre-intervention survey.
干预措施: Default-style LLM chatbot (Behavioral)
Conversational-style LLM chatbot
A large language model chatbot (GPT-4o) that delivers tailored persuasive messages to parents about HPV vaccination in a conversational style, with short responses. Participants engage in a three-minute, multi-turn conversation, with responses personalized to their top-rated vaccine concern identified in a pre-intervention survey.
干预措施: Conversational-style LLM chatbot (Behavioral)
Public health informational materials
Official public health informational materials on HPV vaccination from the Centers for Disease Control and Prevention (U.S.), National Health Service (U.K.), or Public Health Agency of Canada, matched to the participant's country of residence. Materials are 589-680 words in length, cover HPV risks and benefits of vaccination, and are presented for three minutes before participants proceed.
干预措施: Public health informational materials (Behavioral)
结局指标
主要结局
Change in intent to vaccinate child against HPV within the next 12 months
时间窗: Baseline to immediately post-intervention
Self-reported likelihood, on a 0-100 scale, of vaccinating the participant's youngest HPV vaccine-eligible child (identified in pre-survey) within the next 12 months. Measured before and immediately after the intervention to assess short-term changes in vaccination intent.
次要结局
- Change in intent to vaccinate child against HPV at 15-day follow-up(Baseline to 15 days post-intervention)
- Change in intent to vaccinate child against HPV at 45-day follow-up(Baseline to 45 days post-intervention)
- Change in importance ratings of HPV vaccine concerns(Baseline to immediately post-intervention)
- Change in general parental vaccine hesitancy (PACV-5)(Baseline to immediately post-intervention)
- Willingness to donate payment to vaccine education charity(Immediately post-intervention)
- Willingness to be recontacted for future research(Immediately post-intervention)
- Ratings of empathy, usefulness, and relevance of intervention content(Immediately post-intervention)
- Change in intent to vaccinate child for influenza and COVID-19(Measured at baseline and immediately post-intervention.)
- Clicks on HPV vaccine appointment scheduling link(Immediately post-intervention)