se of radiation treatment after surgery for small Oral cancers.

Phase 2

• Conditions: Health Condition 1: null- Early stage oral tongue cancersHealth Condition 2: C04- Malignant neoplasm of floor of mouthHealth Condition 3: C03- Malignant neoplasm of gumHealth Condition 4: C02- Malignant neoplasm of other and unspecified parts of tongue

• Registration Number: CTRI/2017/07/009114
• Lead Sponsor: ational Cancer Grid

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 17 October 2022

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1.Post-operative early stage squamous cell carcinoma of oral cavity (Oral Tongue, Buccal Mucosa, Floor of mouth).

(pT1, pT2, N0 as defined in the AJCC Classification 8th edition.

pT2 is defined in AJCC 8th edition as

i. Tumor < 2cm and depth of invasion > 5mm and � 10mm.

ii. Tumor > 2cm but � 4cm and depth of invasion (DOI) � 10mm.)

2.Adequate surgery (Defined as wide local excision of primary tumor with tumor free margin � 5mm and ipsilateral selective neck dissection addressing levels I-III at minimum.)

3.Written informed consent.

4.Age �18 years

5.Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2

6.Depth of invasion (DOI) � 5 mm.

7.Compliance to therapy and follow-up

8.Interval from surgery to adjuvant radiotherapy � 8 weeks

Exclusion Criteria

1.pT3/pT4 (as specified in the AJCC 8th edition).

2.Depth of invasion < 5mm.

3.Any neck nodal metastasis with or without extra nodal extension.

4.Tumor free margin < 5 mm

5.Non-squamous histology

6.Pregnant woman

7.Prior h/o any other malignancy in the last five years

8. Prior therapeutic irradiation of the head and neck.

9. Presence of HIV infection

Study & Design

• Study Type: Interventional
• Study Design: Not specified