Incidence of High Levels of Transpulmonary Pressure During the Use of Airway Pressure Release Ventilation.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Transpulmonary pressure
研究概览
简要总结
Mechanical ventilation can induce pulmonary lesions called ventilator induced lung injury (VILI). High levels of Transpulmonary pressure is one of the most important mechanism of VILI during the use of mechanical ventilation. The use of bilevel pressure ventilator modes like APRV could generate high levels of transpulmonary pressure.
The aim of this study is to evaluate the variations of transpulmonary pressure during the use of APRV by clinicians
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient mechanically ventilated for more than 48 H for acute respiratory failure
- •Decision to use of the APRV mode by clinicians in charge of the patient
排除标准
- •Contraindication for the use of a nasogastric tube
研究组 & 干预措施
Patient mechanically ventilated with APRV mode
干预措施: evaluate the variations of transpulmonary pressure during the use of APRV by clinicians. (Other)
结局指标
主要结局
Transpulmonary pressure
时间窗: 24 hours
Measurement of transpulmonary pressure needs the measurement of oesophageal pressure with a specific nasogastric tube. This measurement is now available in routine in few mechanical ventilators in intensive care units (eg: AVEA Ventilator. Vyasys HealthCare). Transpulmonary pressure is the difference between airway pressure and oesophageal pressure and it is now easy to obtain and monitor at the bedside with these ventilators. It is also possible to record the value furthermore than 24 hours.
次要结局
- Maximal value of transpulmonary pressure(24 hours)