Incidence of High Levels of Transpulmonary Pressure During the Use of Airway Pressure Release Ventilation.
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Patient Mechanically Ventilated With APRV Mode
- Sponsor
- Assistance Publique Hopitaux De Marseille
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Transpulmonary pressure
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
Mechanical ventilation can induce pulmonary lesions called ventilator induced lung injury (VILI). High levels of Transpulmonary pressure is one of the most important mechanism of VILI during the use of mechanical ventilation. The use of bilevel pressure ventilator modes like APRV could generate high levels of transpulmonary pressure.
The aim of this study is to evaluate the variations of transpulmonary pressure during the use of APRV by clinicians
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patient mechanically ventilated for more than 48 H for acute respiratory failure
- •Decision to use of the APRV mode by clinicians in charge of the patient
Exclusion Criteria
- •Contraindication for the use of a nasogastric tube
Outcomes
Primary Outcomes
Transpulmonary pressure
Time Frame: 24 hours
Measurement of transpulmonary pressure needs the measurement of oesophageal pressure with a specific nasogastric tube. This measurement is now available in routine in few mechanical ventilators in intensive care units (eg: AVEA Ventilator. Vyasys HealthCare). Transpulmonary pressure is the difference between airway pressure and oesophageal pressure and it is now easy to obtain and monitor at the bedside with these ventilators. It is also possible to record the value furthermore than 24 hours.
Secondary Outcomes
- Maximal value of transpulmonary pressure(24 hours)