Transpulmonary Pressure and Airway Pressure Release Ventilation (APRV).

Not Applicable

Completed

• Conditions: Patient Mechanically Ventilated With APRV Mode
• Interventions: Other: evaluate the variations of transpulmonary pressure during the use of APRV by clinicians.

• Registration Number: NCT02866513
• Lead Sponsor: Assistance Publique Hopitaux De Marseille

Brief Summary

Mechanical ventilation can induce pulmonary lesions called ventilator induced lung injury (VILI). High levels of Transpulmonary pressure is one of the most important mechanism of VILI during the use of mechanical ventilation. The use of bilevel pressure ventilator modes like APRV could generate high levels of transpulmonary pressure.

The aim of this study is to evaluate the variations of transpulmonary pressure during the use of APRV by clinicians

Detailed Description

Not available

Study Timeline

• Study Start: 2016-02
• Status Verified: 2016-08
• Study First Submitted: 2016-08-02
• Study First Submitted QC: 2016-08-10
• Study First Posted: 2016-08-15
• Primary Completion: 2016-12
• Study Completion: 2017-03
• Last Update Submitted: 2017-11-13
• Last Update Posted: 2017-11-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Adult
• Patient mechanically ventilated for more than 48 H for acute respiratory failure
• Decision to use of the APRV mode by clinicians in charge of the patient

Exclusion Criteria

• Contraindication for the use of a nasogastric tube

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Patient mechanically ventilated with APRV mode	evaluate the variations of transpulmonary pressure during the use of APRV by clinicians.	-

Primary Outcome Measures

Name	Time	Method
Transpulmonary pressure	24 hours	Measurement of transpulmonary pressure needs the measurement of oesophageal pressure with a specific nasogastric tube. This measurement is now available in routine in few mechanical ventilators in intensive care units (eg: AVEA Ventilator. Vyasys HealthCare). Transpulmonary pressure is the difference between airway pressure and oesophageal pressure and it is now easy to obtain and monitor at the bedside with these ventilators. It is also possible to record the value furthermore than 24 hours.

Secondary Outcome Measures

Name	Time	Method
Maximal value of transpulmonary pressure	24 hours	Value of tidal volume \> 8 ml/kg

Trial Locations

Locations (1)

Assistance Publique Hôpitaux de Marseille hôpital de la Timone; 🇫🇷 Marseille, France