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Clinical Trials/NCT07048717
NCT07048717Active, not recruitingNot Applicable

The Mauritius and Rodrigues Non-Communicable Disease (NCD) Study

Umeå University0 sites39,082 target enrollmentStarted: July 2, 2025Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Active, not recruiting
Enrollment
39,082
Primary Endpoint
Mortality

Study Overview

Brief Summary

Mauritius is located in the southern Indian Ocean with a population of 1.3 million in 2023. Mauritius is a multiethnic nation with 68% South Asian, 27% African (Creole), 3% Chinese and 2% Franco Mauritians.

Seven population-based cross-sectional surveys using standardised protocols were conducted between 1987 and 2021). The participation rate has been over 85% in each survey.

At each survey, participants were interviewed about living conditions, lifestyle and health, and anthropometry and blood pressure were measured. Biochemistry including lipids and an oral glucose tolerance test (OGTT) were performed Electrocardiograms (ECG) were recorded in participants aged 35 years and older. Previous participants were followed up in 2007 and 92% were successfully traced.

Studies with identical methodology have been performed on the neighbouring island Rodrigues where the majority of the population are Creoles.

Detailed Description

Mauritius and Rodrigues are islands in the south-eastern part of the Indian Ocean. Major changes in lifestyle have been seen during the last fifty years, including less physical activity and introduction of a westernised diet. In parallel, the disease panorama has changed from high infant mortality and infectious diseases to lifestyle-related diseases such as cardiovascular disease and type 2 diabetes.

The population in Mauritius are descendants to immigrants from South Asia, Africa and China, i.e., approximately 60% of the world population are represented. Mauritius is probably the only developing country that has followed the development of non-communicable diseases (NCD) and associated risk factors over a long time-period and continues to do so.

In the mid-eighties, the Mauritian government initiated a study on the prevalence of type 2 diabetes and cardiovascular disease, in collaboration with WHO and international experts. Altogether seven population-based surveys have been performed between 1987 and 2021, and approximately 39 000 (!) examinations have been recorded. The intention is to repeat the survey every fifth year.

The ethnicities of the participants have been 71% South Asians (India/Pakistan), 24% Creoles (Africa) and 5% Chinese, which reflects well the ethnical distribution of the population. Previous participants were followed up in 2007 and 92% were successfully traced. Studies have also been performed on the neighbouring island Rodrigues where the majority of the population are Creoles. During the follow-up survey in 2010, 97% of the 9 700 participants were traced.

At each survey, information was given and an individual consent form was signed. See attached the local (in Mauritius) ethical approval and consent form from the Mauritius survey 2021.

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Cross Sectional

Eligibility Criteria

Ages
25 Years to 74 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Not provided

Exclusion Criteria

  • Not provided

Outcomes

Primary Outcomes

Mortality

Time Frame: Up to 20 years from the baseline survey

According to household interviews, death certificates from central registers at Ministry of Health and Wellness. 1. Household interviews: "Is the participant alive? If dead, do you have a copy of the death certificate? When did the participant die?" 2. Central registers: Vital status, if dead, date and cause of death from death certificates" Combining 1 and 2 will give date and cause of death. Absolute numbers and mortality rates will be reported for all and in subgroups i.e. sex, age-strata, ethnicity.

Secondary Outcomes

  • Diabetes Mellitus(Up to 20 years from the baseline survey)
  • Cardiovascular disease (CVD)(Up to 20 years from the baseline survey)
  • Hypertension(Up to 20 years from the baseline survey)
  • Obesity(Up to 20 years from the baseline survey)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Stefan Soderberg

Professor, consultant

Umeå University

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