The effect of bronchodilation and bronchoconstiction on airway closure, low ventilation and distribution of ventilation in COPD and asthma using SPECT.

Woolcock Institute of Medical Research0 sites70 target enrollmentMarch 19, 2019

Overview

No summary available.

Registry

who.int

Start Date

March 19, 2019

End Date

TBD

Last Updated

6 years ago

Study Type

Interventional

Sex

All

Sponsor

•1\. Willing and able to give written informed consent
•2\. Have a physician\-diagnosed COPD or asthma
•3\. For asthma only:
•\- no history of smoking or smoking history of less that 10 pack years
•4\. For COPD only:
•\- history of current or past smoking, with total exposure of greater than 10
•pack years.
•\- FEV1/FVC ratio of less the 95th percentile of the normal range (according to subject
•age, gender and height); AND
•\- FEV1 less the 95th percentile of the normal range predicted for subject age, gender and

•1\. Significant cardiac disease (ischemic heart disease or arrhythmia) deemed by the investigators or the subject’s treating cardiologist to make it unsafe for the subject to undertake a supervised near\-maximal exercise test.
•2\. Documented hypersensitivity to, or intolerance of anti\-cholinergic therapies.
•3\. Significant respiratory infection or documented exacerbation of Asthma or COPD within the previous 6 weeks.
•4\. Intensive Care Unit admission in the last 12 months.
•5\. Other active or chronic respiratory pathologies (for example, interstitial lung disease, asthma, chest wall pathology causing ventilatory restriction).
•6\. Past history of lung surgery (including lobectomy or pneumonectomy, but not lung biopsy) or thoracic radiation therapy (excluding isolated mediastinal radiation therapy with no evidence of subsequent pulmonary fibrosis).
•7\. Any major comorbidities deemed to impact on respiratory physiology or symptoms, including severe on uncontrolled heart failure, morbid obesity (BMI \>40\), muscular or neurological disorders causing respiratory muscle weakness or dysfunctional swallowing.
•8\. History of chronic kidney disease (creatine greater than the upper limit of normal).
•9\. Unable to perform lung function testing.
•10\. Dependence on domiciliary supplemental oxygen, unable to go without for at least 1 hour.