ACTRN12619000447156
Not Yet Recruiting
N/A
The effect of bronchodilation and bronchoconstiction on airway closure, low ventilation and distribution of ventilation in COPD and asthma using SPECT.
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Woolcock Institute of Medical Research
- Enrollment
- 70
- Status
- Not Yet Recruiting
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Willing and able to give written informed consent
- •2\. Have a physician\-diagnosed COPD or asthma
- •3\. For asthma only:
- •\- no history of smoking or smoking history of less that 10 pack years
- •4\. For COPD only:
- •\- history of current or past smoking, with total exposure of greater than 10
- •pack years.
- •\- FEV1/FVC ratio of less the 95th percentile of the normal range (according to subject
- •age, gender and height); AND
- •\- FEV1 less the 95th percentile of the normal range predicted for subject age, gender and
Exclusion Criteria
- •1\. Significant cardiac disease (ischemic heart disease or arrhythmia) deemed by the investigators or the subject’s treating cardiologist to make it unsafe for the subject to undertake a supervised near\-maximal exercise test.
- •2\. Documented hypersensitivity to, or intolerance of anti\-cholinergic therapies.
- •3\. Significant respiratory infection or documented exacerbation of Asthma or COPD within the previous 6 weeks.
- •4\. Intensive Care Unit admission in the last 12 months.
- •5\. Other active or chronic respiratory pathologies (for example, interstitial lung disease, asthma, chest wall pathology causing ventilatory restriction).
- •6\. Past history of lung surgery (including lobectomy or pneumonectomy, but not lung biopsy) or thoracic radiation therapy (excluding isolated mediastinal radiation therapy with no evidence of subsequent pulmonary fibrosis).
- •7\. Any major comorbidities deemed to impact on respiratory physiology or symptoms, including severe on uncontrolled heart failure, morbid obesity (BMI \>40\), muscular or neurological disorders causing respiratory muscle weakness or dysfunctional swallowing.
- •8\. History of chronic kidney disease (creatine greater than the upper limit of normal).
- •9\. Unable to perform lung function testing.
- •10\. Dependence on domiciliary supplemental oxygen, unable to go without for at least 1 hour.
Outcomes
Primary Outcomes
Not specified
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