The effect of stimulus patterns on the mismatch negativity in patients with schizophrenia
- Conditions
- DSM-IV 295.30 Schizophrenia, paranoid typeDSM-IV 295.10 Schizophrenia, disorganized typeDSM-IV 295.90 Schizophrenia, undifferentiated typeDSM-IV 295.60 Schizophrenia, residual typeDSM-IV 295.40 Schizophreniform disorderDSM-IV 295.70 Schizoaffective disorderDSM-IV 297.1 Delusional disorderF20F25F22SchizophreniaSchizoaffective disordersPersistent delusional disorders
- Registration Number
- DRKS00004756
- Lead Sponsor
- Klinik für Psychiatrie und Psychotherapie, LVR-Klinikum Essen, Universität Duisburg Essen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Patients: DSM-IV Schizophrenia diagnosis: 295.30, 295.10, 295.9, 295.60, 295.40, 295.70, 297.1;
Patients: stable medication since two weeks;
healthy controls: no psychiatric disorder (for example a major depression);
MWT-B IQ > 75;
fluency of German language;
voluntary written consent
Exclusion Criteria
Impaired hearing;
neurological or neurodegenerative disorder,
persisting or past substance abuse;
acut or chronic inflammatory disease of the nervous system, other serious physical diseases or
malignant tumors
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary outcome is the amplitude of the mismatch negativity in the lantency range of 120 ms to 260 ms following stimulus onset
- Secondary Outcome Measures
Name Time Method Secondary outcome is the performance in study participants in the neuropsychological assessment and the expression of clinical symptoms as assessed with the Positive and Negative Syndrome Scale (PANSS). Neuropsychological assessments include: The German Merfachwahl Wortschatz Test (MWT-B), the Digit Symbol Test (ZST), Syndrome short Test (SKT) and the Trail Making Test Part A +B (TMT A/B).