The Effect of a Five Week Electrical Myostimulation Program in Chronic Diseases

Not Applicable

• Conditions: Heart Failure
• Interventions: Procedure: Functional electrical stimulation; Procedure: Burst-modulated alternating current; Procedure: Placebo; Procedure: Medium-frequency alternating current

• Registration Number: NCT01695421
• Lead Sponsor: University of Brasilia

Brief Summary

Patients afflicted with Chronic Heart Failure (HF) typically do not maintain stable cardiac function for the remainder of their life and consequently require continuous medical management and intermittent hospital admissions. Several investigations have demonstrated that electrical muscle stimulation (EMS) produces positive physiologic and psychological adaptations in patients with HF. However not all the EMS modalities were been evaluated on this population or not even were tested based on present recognized gold standard clinical parameters after a short period of treatment. The primary aims of the proposed study is to: Determine the effect of a five week home based of three EMS modalities on prognostics markers, perceived quality of life, muscle force and electrical activity in subjects diagnosed with HF.

Detailed Description

Introduction: Chronic Heart Failure (HF) patients are a significant health care burden in many countries. Patients afflicted with HF typically do not maintain stable cardiac function for the remainder of their life and consequently require continuous medical management and intermittent hospital admissions. Several investigations have demonstrated that electrical muscle stimulation (EMS) produces positive physiologic and psychological adaptations in patients with HF. However not all the EMS modalities were been evaluated on this population or not even were tested based on present recognized gold standard clinical parameters after a short period of treatment. The impact of use of low frequency (FES) and medium-frequency currents (MAC and BMAC) as EMS on the VE/VCO2 and BNP has likewise not been investigated in patients with HF.

Purposes: The primary aims of the proposed study is to: Determine the effect of a five week home based EMS modalities (a) Functional electrical stimulation (FES), (b) medium-frequency alternating current (MAC) and (c) burst-modulated medium-frequency alternating current (BMAC) training program on the VE/VCO2 slope, Brain Natriuretic Peptide (BNP) level, peak VO2, VO2 at Ventilatory Threshold (VT), perceived quality of life, muscle force and electrical activity in subjects diagnosed with HF (NYHA III and IV). Examine changes in the previously outlined outcome measurements five weeks after cessation of the EMS ((a) FES, (b) MAC and (c) BMAC) training program.

Procedures: We will recruit 40 persons (10 for each EMS modalities and 10 control subjects) diagnosed with HF. A group of control subjects will participate using a sham current. The protocol can be conceptually divided into four sections in the following chronological sequence: (1) baseline assessment (body composition by a bone densitometer X-ray Dual energy X-Ray absortometry - DXA, Resting blood pressure and heart rate, complete blood count and BNP analysis); Living with Heart Failure Questionnaire (MLWHFQ); A physician-supervised maximal aerobic exercise test using a metabolic cart (Vmax, Viasys, USA) (VO2, VE/VCO2, VT); isokinetic peak torque (Biodex System III, Isokinetic Dynamometer, Biodex Medical, Inc., Shirley, NY) and electrical activity (Miotec, Brazil), (2) five week EMS training program (bilateral quadriceps and gastrocnemius for 5 days a week for 1 hour to each muscle group with FES, MAC and BMAC training program), (3) immediate post-training assessment within 5 days of completion of the EMS training program and a (4) final analysis five weeks after cessation of the EMS training program.

Study Timeline

• Status Verified: 2012-09
• Study First Submitted: 2012-09-19
• Study First Submitted QC: 2012-09-26
• Study First Posted: 2012-09-28
• Study Start: 2012-11
• Last Update Submitted: 2013-06-06
• Last Update Posted: 2013-06-10
• Primary Completion: 2013-07
• Study Completion: 2015-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• (1) Male or female ≥ 21 and ≤ 80 years of age.
• (2) Current HF symptoms consistent with NYHA class III-IV.
• (3) On stable HF pharmacological therapy for at least one month prior to data collection.
• (4) Left ventricular ejection fraction < 45% documented within 3 months of enrollment (obtained from subjects medical records).
• (5) No planned elective surgery or pacemaker implantation at the time of study initiation.
• (6) Hgb > 8.0 within 1 month of enrollment (obtained from subjects medical records).
• (7) Willingness to provide written informed consent.

Exclusion Criteria

• (1) Inability to provide written informed consent.
• (2) Inability to walk on a treadmill.
• (3) Hemodynamically significant valvular heart disease.
• (4) Unstable angina.
• (5) Acute myocardial infarction within the previous 3 months.
• (6) Obstructive hypertrophic cardiomyopathy.
• (7) HF known to be secondary to pericardial disease or uncorrected valvular disease.
• (8) Chronic oxygen therapy.
• (9) Participation in another clinical trial within the past 30 days.
• (10) Participation in a regular exercise within the previous 6 months.
• (11) Previous implantation of a cardiac pacemaker or defibrillator.
• (12) Pregnancy.
• (13) Resting systolic blood pressure > 200 mmHg.
• (14) Failure to demonstrate the ability to operate the EMS unit.
• (15) Failure to be compliant with at least 75% of the EMS training sessions.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Functional electrical stimulation	Functional electrical stimulation	Burst modulated alternating rectified current with a 10 Hz carrier frequency, 400 microsecond pulse duration and 50 Hz bursts
Burst-modulated alternating current	Burst-modulated alternating current	Burst modulated alternating current with a 4000 Hz carrier frequency, 400 microsecond pulse duration and 50 Hz bursts.
Placebo	Placebo	Training with the intensity of 5 mA.
Medium-frequency alternating current	Medium-frequency alternating current	Burst modulated alternating current with a 2500 Hz carrier frequency, 400 microsecond pulse duration and 50 Hz bursts

Primary Outcome Measures

Name	Time	Method
VE/VCO2 slope	Change from Baseline in VE/VCO2 slope at five and ten weeks post EMS.

Secondary Outcome Measures

Name	Time	Method
Peak VO2	Change from Baseline in Peak VO2 at five and ten weeks post EMS.
VO2 at Ventilatory Threshold	Change from Baseline in VO2 at ventilatory threshold at five and ten weeks post EMS.
Muscle force	Change from Baseline in muscle force at five and ten weeks post EMS.
Muscle electrical activity	Change from Baseline in muscle electrical activity at five and ten weeks post EMS.
Perceived quality of life	Change from Baseline in perceived quality od life at five and ten weeks post EMS.
Brain Natriuretic Peptide level	Change from Baseline in Brain Natriuretic Peptide Level at five and ten weeks post EMS.

Trial Locations

Locations (1)

Brasilia University; 🇧🇷 Brasilia, Federal District, Brazil