Effect of Mechanical Load Magnitude on Reflex Latency Induced by Whole-Body Vibration: A Latency-Based Evaluation of Bone Myoregulation Reflex and Tonic Vibration Reflex
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Reflex latency (milliseconds) in the soleus muscle during vibration stimulation
研究概览
简要总结
This study aims to investigate how the magnitude of mechanical loading affects reflex latency patterns induced by whole-body vibration (WBV). WBV can trigger two types of reflexes: the tonic vibration reflex (TVR) and the bone myoregulation reflex (BMR), which may be influenced by load-bearing condition. The study will include healthy adult volunteers aged 20-50 years. Reflex responses will be recorded from the soleus muscle using surface EMG during both WBV. Different conditions of mechanical loading (i.e., standing on one foot, both feet) and vibration frequencies (30-36 Hz) will be tested. The main outcome will be the latency of the reflex responses, which will help distinguish between TVR and BMR activation. The goal is to better understand how mechanical load modifies reflex response timing and to characterize the underlying afferent pathways. This knowledge may contribute to optimizing vibration-based rehabilitation strategies.
详细描述
This study investigates how the magnitude of mechanical loading alters reflex latency patterns during whole-body vibration (WBV), focusing specifically on the tonic vibration reflex (TVR) and the bone myoregulation reflex (BMR). Experimental data suggest that WBV may activate different reflex mechanisms depending on the level of postural loading, frequency, and amplitude of the vibration. Previous studies have shown that low-amplitude WBV tends to activate TVR under voluntary contraction, while higher mechanical loads and neutral standing posture are more likely to induce BMR.
Surface electromyography (sEMG) recordings will be obtained from the soleus muscle during vibration stimuli applied at different frequencies (30, 32, 34, and 36 Hz). Recordings will be taken under multiple loading conditions: standing on both feet, standing on one foot. Reflex latency will be calculated using cumulative averaging techniques, and data will be analyzed offline using Spike2 software.
Findings from this study may contribute to a deeper understanding of reflex integration during vibratory stimulation and inform future neurorehabilitation protocols that utilize WBV as a therapeutic modality.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged between 18 and 40 years
- •Healthy adult volunteers with no known neurological or musculoskeletal disorders
- •Able to provide informed consent
- •Willing to comply with the procedures of the study, including EMG and vibration exposure
排除标准
- •History of any neurological condition (e.g., peripheral neuropathy, spinal cord injury, stroke)
- •Musculoskeletal injury or surgery involving the lower extremities
- •Use of medications affecting neuromuscular function
- •Pregnancy
- •Presence of implanted electronic devices (e.g., pacemaker)
- •Known intolerance to vibration exposure
研究组 & 干预措施
Whole-Body Vibration in Healthy Volunteers
Participants will receive whole-body vibration (WBV) under mechanical loading conditions. Surface EMG recordings from the soleus muscle will be used to evaluate reflex latency at vibration frequencies of 30, 32, 34, and 36 Hz. All interventions will be applied in a single-session experimental design in healthy adult volunteers.
干预措施: Whole-Body Vibration (Device)
结局指标
主要结局
Reflex latency (milliseconds) in the soleus muscle during vibration stimulation
时间窗: Day 1 (single-session, during each experimental condition)
Reflex latency will be calculated based on surface EMG recordings from the soleus muscle during whole-body vibration at frequencies of 30-36 Hz. Latency will be analyzed using cumulative averaging techniques and expressed in milliseconds.
Reflex latency (milliseconds) in the soleus muscle during vibration stimulation
时间窗: Day 1 (single-session, during each experimental condition)
Reflex latency will be calculated based on surface EMG recordings from the soleus muscle during whole-body vibration at frequencies of 30-36 Hz. Latency will be analyzed using cumulative averaging techniques and expressed in milliseconds.
次要结局
- Effect of vibration frequency on reflex latency and amplitude(Day 1 (single-session, during each experimental condition))
- EMG amplitude of reflex response in the soleus muscle during vibration stimulation(Day 1 (single-session, during each experimental condition))
- Reflex type classification (TVR vs BMR) based on latency and mechanical load(Day 1 (single-session, during each experimental condition))
- Reflex latency variability under different mechanical loading conditions(Day 1 (single-session, during each experimental condition))
- EMG amplitude of reflex response in the soleus muscle during vibration stimulation(Day 1 (single-session, during each experimental condition))
- Reflex type classification (TVR vs BMR) based on latency and mechanical load(Day 1 (single-session, during each experimental condition))
- Reflex latency variability under different mechanical loading conditions(Day 1 (single-session, during each experimental condition))
- Effect of vibration frequency on reflex latency and amplitude(Day 1 (single-session, during each experimental condition))
研究者
Selim Sezikli
Principal Investigator / Physical Medicine & Rehabilitation Specialist
Istanbul Physical Medicine Rehabilitation Training and Research Hospital