One-stop Evaluation of Hypertrophic Cardiomyopathy in Cardiac Magnetic Resonance
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 10,000
- 主要终点
- Number of participants with sudden cardiac death
研究概览
简要总结
This is a multi-center, observational study aiming to establish a precision diagnosis scheme and multi-dimensional risk prediction models for Hypertrophic Cardiomyopathy (HCM). The study plans to enroll 10000 adult HCM patients. It will integrate genetic testing, advanced cardiac imaging (echocardiography and cardiac magnetic resonance), and biomarker analysis to develop early diagnosis, differential diagnosis, and new risk prediction models for sudden cardiac death (SCD) and heart failure in HCM patients. Participants will undergo baseline assessments and be followed up every six months for up to 3 years to track clinical outcomes. This study is non-interventional and does not involve any investigational drugs or devices.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •A maximal left ventricular wall thickness of ≥ 12 mm in any segment at end-diastole, as measured by echocardiography or Cardiac Magnetic Resonance (CMR)
排除标准
- •Presence of any contraindication to CMR examination.
- •Unwillingness to participate in the study or to provide informed consent.
研究组 & 干预措施
hypertrophic myocardium
结局指标
主要结局
Number of participants with sudden cardiac death
时间窗: 5-year
次要结局
- Number of participants with all-cause mortality(5-year)
- Number of participants with atrial fibrillation(5-year)
- Number of participants with heart failure hospitalization(5-year)
研究者
Minjie Lu
Principal Investigator
Chinese Academy of Medical Sciences, Fuwai Hospital