Effect of intraoperative low-dose naloxone infusion on postoperative pain control
Not Applicable
Recruiting
- Conditions
- Not Applicable
- Registration Number
- KCT0000515
- Lead Sponsor
- Asan Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
1. elective living-donor hepatectomy
2. who consented present study
3. over 20 yr old
Exclusion Criteria
1. alleric history to naloxone
2. postoperative intubating state
3. sedated patient
4. cannot verbal communication
5. do denied to participate
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Visual Analogue Pain Scale;fentanyl requirement
- Secondary Outcome Measures
Name Time Method rescue analgesic requirement;blood pressure; heart rate
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie naloxone's opioid receptor antagonism in postoperative pain modulation?
How does intraoperative low-dose naloxone compare to standard opioid-based analgesia in postoperative pain control efficacy?
Are COMT or OPRM1 polymorphisms predictive of naloxone response in postoperative pain management trials?
What adverse events are associated with low-dose naloxone infusion during surgery and how are they managed?
What combination therapies with non-opioid analgesics enhance naloxone's postoperative pain control outcomes?