Acute Pancreatitis: A Comprehensive Exploration of immune lineages.
- Conditions
- Acute pancreatitis10017969
- Registration Number
- NL-OMON46341
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 80
Patients
In order to be eligible to participate in this study, a subject must meet all of the following criteria:
Suspected acute biliary, alcoholic or idiopathic pancreatitis
At least 2 out of 3 criteria of acute pancreatitis:
- Pain in upper abdomen
- Serum amylase and/or lipase >3x upper limit of normal (ULN)
- Signs of acute pancreatitis on CT or MR
* 18 years old
Provide informed consent;Healthy volunteers
A person is eligible to participate as healthy volunteer if they are considered to be healthy and if their age and gender matches with a patient included in this study.
Use of medications with possible immune-modulating effects (e.g., steroids or recent chemotherapy)
Time from onset of abdominal pain to hospital admission >48 hours
Established diagnosis of chronic pancreatitis
Suspected cholangitis;Healthy volunteers
Use of medications with possible immune-modulating effects (e.g., steroids or recent chemotherapy)
Current or recent (in the last two weeks) infectious disease (i.e. influenza)
Systemic diseases
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameters are immune subsets which consist of a clustering of<br /><br>peripheral blood leukocytes. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary study parameters include serum urea, CRP, leukocyte counts,<br /><br>mortality, morbidity, days of admission, prognostic scores, medical history,<br /><br>medication, alcohol and drug use.</p><br>