Evaluation of Post Infectious Inflammatory Reaction (PIIR) Concerning Children After Streptococcus Pneumoniae, Streptococcus Pyogenes and Neisseria Meningococcus Invasive Infection

• Conditions: Streptococcus Pneumonia; Streptococcus Pyogenes Infection; Neisseria Meningitides Meningitis

• Registration Number: NCT04594785
• Lead Sponsor: University Hospital, Montpellier

Brief Summary

As Covid 19 manifestations that have been recently described, inflammatory manifestation have major impact in infectious disease lesions. Some of them are delayed and provide Post infectious inflammatory reaction (PIIR), they are challenging for diagnosis and for management. Clinician have to avoid unnecessary antibiotic thearapy and in if necessary have to give immunosuppressive therapy. Except for rheumatic disease for group A streptococcus (GAS) infections there are not stanrdized diagnostic criteria and therapeutic protocol, and PIIR have probably a suboptimal management. In this context the investigators aim to explore PIIR in the 3 most frequent bacterial invasive infection in France, by a retrospective monocentric study. The investigators include all children betwwen 2012 and 2018 hospitalized for infections by Streptococcus pneumoniae (SP), Neisseria meningitidis (NM), and GAS invasive infections.

Detailed Description

Not available

Study Timeline

• Status Verified: 2020-10
• Study Start: 2020-10-01
• Study First Submitted: 2020-10-13
• Study First Submitted QC: 2020-10-13
• Study First Posted: 2020-10-20
• Last Update Submitted: 2020-10-26
• Last Update Posted: 2020-10-28
• Primary Completion: 2021-12-01
• Study Completion: 2021-12-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Describe the frequency PIIRs	1 day	Describe the frequency PIIRs following invasive pneumococcal, meningococcal, or group A Streptococcal infection

Secondary Outcome Measures

Name	Time	Method
Characteristics PIIRs following invasive pneumococcal, meningococcal, or group A Streptococcal infection	1 day	Describe the characteristics PIIRs following invasive pneumococcal, meningococcal, or group A Streptococcal infection

Trial Locations

Locations (1)

Uhmontpellier; 🇫🇷 Montpellier, France